Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation occurs during development of an organism to produce new specialised cells, and also in adults to ...
Cell differentiation occurs through changes in gene expression A central concept - master regulators unleash 释放 genetic regulatory cascades During vertebrate development, signals received by some cells cause the expression of a gene called MyoD. The product of this gene acts as a transcription factor...
A high proportion of the DNA demethylation taking place during cell differentiation occurs in genomic regions namedpartially methylated domains(PMDs), which are characterized by late replication and passive demethylation22,23. To test whether the impaired DNA demethylation observed in CVID S-mem B cell...
“Positive regulation of cell proliferation” “cell differentiation” and “positive regulation of cell migration” were also enriched in B-LMO2 cells, suggesting potential associations with other cellular interactions. B-STMN1 was related to “cell division”, “positive regulation of cell ...
The morphological and molecular data presented here show that xylem cell differentiation occurs via a switch-like mechanism stimulated by VND7, but not MYB46 or MYB83. The single-cell transcriptome data provide an opportunity to identify the network topology needed for xylem cell differentiation usin...
[34,35]. Specifically, after stimulation at the initial target, SynNotch induces the expression of CAR in T cells. Then T cell activation ensues as the CAR binds to the antigen on target cells. T cell activation occurs only when tumor cells express two specific surface antigens simultaneously...
Hypothetically, disintegration occurs as a result of the liquid surface hitting the cell wall during implosion of gas bubbles. High pressure homogenizers are used on an industrial scale, as they make it possible to achieve a high output in continuous operation. Carrying out the disintegration ...
seq is a broadly applicable technology, enabling empirical measurements of differentiation trajectories, which can enhance the development of more efficacious immunotherapies. 破译免疫适应背后细胞状态的转变是推进生物学发展的基础。目前缺少捕...
Cell number and cell size are the two main factors that determine the leaf size. But the leaf area is not a simple sum of cell number and cell size, it’s under the co-ordination of them18,19,20. During the whole primordium, cell division occurs and generates new cells, the size of...
The process of programmed cell death that occurs when epithelial cells lose contact with the surrounding extracellular matrix. Neural crest Group of cells emanating from the embryonic neurectoderm during development that develop through complex migration patterns into a wide variety of cell types, includi...