Tumor cell line-derived xenograft subtype shapes tumor microenvironment composition in BRGSF-HIS mice BRGSF-HIS小鼠适用于构建多种CDX/PDX模型,通过分析肿瘤微环境(TME)的组成,有助于为患者筛选和匹配更为精准的治疗方案。我们在HIS...
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作者阐述了现有的黑色素瘤常用模型,包括基因工程小鼠模型(Genetically engineered mouse models)、同系模型(Syngeneic models)、患者来源的异种移植模型(Patient-derived xenograft models)、类器官黑色素瘤模型(Organoids as melanoma models)、其他先进的体外黑色素瘤模型 (Other advanced in vitro melanoma models)。
Nakamura, S.,Hocking,etc.Development and analysis of patient-derived xenograft mouse models in intravascular large B-cell lymphoma[J].2016,30(7).Shimada K, Shimada S, Sugimoto K, Nakatochi M, Suguro M, Hirakawa A, et al. Development and analysis of patient- derived xenograft mouse models ...
Finally, we showed for the first time the effectiveness of antibody-mediated functional inhibition of CDCP1 at reducing growth of a patient-derived xenograft (PDX) mouse model. These data suggest that CDCP1 has an important and targetable role in HGSC. Materials and methods Patient samples and ...
领域内广泛应用的病人源异种移植（Patient-derived xenograft, PDX）模型（包括胶质瘤干细胞移植模型）反映的是终末期肿瘤的性质。而现有的GBM转基因小鼠模型由于存在人鼠肿瘤差异以及成瘤位置的不确定性，对于模拟和分析hNSC的成瘤路径也不够理想。 2021年1月4日，四川大学华西医院生物治疗国家重点实验室汪源/陈路/...
This xenograft model is superior to other models because the tumor is implanted into the same physiological space where ovarian cancer is found, which allows for improved mimicking of actual disease. 展开 关键词: Bioluminescent imaging Immunotherapy Mouse xenograft Natural killer cells Ovarian cancer ...
Investigating the potential role of stem cells in the initiation and progression of breast cancer metastases, Lawson and colleagues [36] developed a fluorescence-activated cell sorting assay to identify human metastatic cells from a patient-derived xenograft (PDX) mouse model. Multiplex analysis ...
(MYH11) in the context of HLA-B*40:01 (ref.31) showed some efficacy in patient-derived xenograft (PDX) mouse models with low AML engraftment. However, no neoantigen-specific TCR has yet been shown to efficiently target primary human AML in in vivo models in which high and increasing ...
The role of LX-2 cell–derived lEV HK1 in promoting HCC progression was further verified in mouse models. Intravenous injection of lEVs derived from control moHSCs but not those derived from HK1 knockdown moHSCs notably promoted the growth of Hepa1-6 cell–derived orthotopic xenograft tumors (Fi...