Patterns of cell death: the significance of apoptosis for dermatology Development, function, remodelling, and senescence of multicellular organisms depend on the coordinated occurrence of physiological, actively induced cell ... R Paus,T Rosenbach,N Haas,... - 《Experimental Dermatology》...
such as the frog’s legs. In the 20th century the medical significance of cell death was recognized by Australian researcher John Foxton R. Kerr and Scottish scientists Andrew H. Wyllie and Alastair Currie. In a paper published in 1972, they used the termapoptosis(from the Greek word meaning...
Cell death: the significance of apoptosis International Review of Cytology, 68 (1980), pp. 251-306 View in ScopusGoogle Scholar Zhang et al., 2009 Y.B. Zhang, Y.P. Yeb, X.D. Wuc, H.X. Sun Astilbotriterpenic acid induces growth arrest and apoptosis in HeLa cells through mitochondria...
The variations seen force a reassessment of those aspects of physiological cell death that are truly universal, thereby focusing attention on the biology of the process. A better understanding of the biology and morphology of dying cells will help clarify the significance of the molecular and ...
apoptosis, therapeutic opportunities of other cell death pathways are often neglected. Molecular heterogeneity of head and neck squamous cell carcinomas (HNSCC) causing unpredictability of the clinical response represents a grave challenge for oncologists and seems to be a critical component of treatment...
Ferroptosis is a unique mode of cell death driven by oxidative stress and iron-dependent phospholipid peroxidation. The morphological and biochemical characteristics of ferroptosis are obviously different from those of other forms of regulated cell death (RCD), such as apoptosis and pyroptosis [2,3]....
Molecular mechanisms of different cell death pathways The most extensively studied RCD modality is apoptosis, which leads to immunogenicity or induces no immunogenic response in different contexts [18,19]. The morphological changes observed during apoptotic cell death include cell shrinkage, externalization...
Tumour evolution is a complex process with many interplaying mechanisms and factors, among these is apoptosis (programmed cell death). Disabling of apoptotic responses might be a crucial contributor not only of tumour cell survival but also the resistance to the anticancer therapy. Initiation of apop...
of keratinocyte stem cells (SCs) maintain the epidermal barrier function and the hair follicle. These SCs are inherently long-lived, but cell death can occur within their niches and impacts their functionality. The default cell death programme in skin is apoptosis, an orderly and non-inflammatory...
Pathogenic human immunodeficiency virus (HIV)/Simian immunodeficiency virus (SIV) infection is associated with increased T-cell apoptosis. In marked contrast to HIV infection in humans and SIV infection in macaques, the SIV infection of natural host spec