作者:Kim Newton, Andreas Strasser, Nobuhiko Kayagaki, Vishva M. Dixit 摘要:Cell death supports morphogenesis during development and homeostasis after birth by removing damaged or obsolete cells. 查看更多 摘要翻译(由计算机程序完成,仅供参考,内容以英文原文为准): 所属学科: 生物 细胞生物学 细胞死亡在生...
A. et al. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8, 297–303 (1998). Article CAS PubMed Google Scholar Newton, K. et al. RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation ...
Keywords: Apoptosis; Necroptosis; Pyroptosis; Inflammation; Survival Cellular & Molecular Immunology (2021) 18:1106–1121; https://doi.org/10.1038/s41423-020-00630-3 INTRODUCTION Cell death has physiological and pathological functions. The cellular lifespan can range from a few days to many years,...
In recent years, it has become evident that the role of many caspases is not limited to apoptosis and that they function in other modes of cell death (necrosis, autophagy and pyroptosis). Furthermore, several other non-cell death functions have emerged. We begin by first addressing the role ...
(IL-1β) are two of the most critical pro-inflammatory cytokines, and their receptors can also activate NFκB to promote further expression of inflammatory genes. This facilitates infiltration of leukocytes into the infected tissue resulting in removal of the pathogen. Cell death can also be an ...
Cell Death Differ. 2013, 20 (10): 1306-1316. 10.1038/cdd.2013.47. Article PubMed Central CAS PubMed Google Scholar Jones DR, Moskaluk CA, Gillenwater HH, Petroni GR, Burks SG, Philips J, Rehm PK, Olazagasti J, Kozower BD, Bao Y: Phase I trial of induction histone deacetylase and...
3.4. YM155 sensitizes NSCLC cells to erlotinib by promoting autophagic cell death and autophagy-dependent apoptosis To determine whether YM155 sensitize NSCLC cells to erlotinib through promoting autophagic cell death and autophagy-related apoptosis, we assess the relationship between erlotinib sensitization...
8,9 Gene-mediated cytotoxic immunotherapy (GMCI) is an in situ vaccination approach that uses aglatimagene besadenovec (AdV-tk), an “armed” non-replicating adenoviral (Ad) vector, to induce immunogenic cancer cell death (e.g., apoptosis, autophagy, necroptosis) and an anti-tumor immune ...
Cell death is a fundamental physiological process in all living organisms. Its roles extend from embryonic development, organ maintenance, and aging to the coordination of immune responses and autoimmunity. In recent years, our understanding of the mecha
cell death, a gene-regulated active cell death. However, necrosis was considered an accidental form of cell death, an uncontrolled passive cell death [1]. However, increasing evidence shows that cell apoptosis is not the unique form of programmed cell death, and regulated necrosis (also termed ...