Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage in cancer therapeutics. Here, we review the cur...
Ferroptosis represents a form of programmed cell death that is propelled by iron-dependent lipid peroxidation, thereby being distinguished by the prominent features of iron accumulation and lipid peroxidation. Ferroptosis has been implicated in numerous
The levels of MDA and intracellular total iron ion also were significantly increased in HK-2 cells exposed to PFOS and the levels of GSH and GPX-4 were significantly decreased. PFOS can damage HK-2 cells through ferroptosis and endoplasmic reticulum stress, which provides a theoretical foundation...
The term ferroptosis was put forward in 2012 and has been researched exponentially over the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed cell death, which belongs to a type of necrosis and is distinguished from apoptosis and autophagy. Actuated by iron-depend...
cell death, there are many aspects that distinguish it as a distinct form of cell death. For instance, ferroptosis is morphologically and functionally distinct from ‘generic’ oxidative stress, such as hydrogen peroxide-induced necrosis [102]. Many molecular components of ferroptosis have been ...
Mechanism of Cu2+overload-induced cell death. Cytoplasmic occurrence of copper overload combined with esteroylated protein aggregation can induce cuprotosis, and oxidizing Cu+ can induce a burst of ROS, causing ferroptosis, autophagy, and apoptosis ...
The oxidized fatty acid products regulate not only apoptosis, but also non-apoptotic cell death induction (ferroptosis, autophagy, and regulated neutrophil cell death in immune response) (44–47). OxDHA may be useful for studying the mechanism of cell death induced by lipid peroxidation, which ...
The score for the depth of inflammatory infiltration was defined as follows: no inflammatory infiltrate in the lamina propria, 0; increased presence of inflammatory cells in the mucosa, 1; inflammatory infiltrate extending into the submucosa or existing necrotic cell death in the crypt lumen, 2; ...
The increased expression of programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) has also been demonstrated to be closely related to KRAS status[11]. Controversial results have been reported in multiple clinical studies on the efficacy of immune checkpoints ...
This study shows a comprehensive overview of the role of ferroptosis in redox biology. Article PubMed PubMed Central Google Scholar Seiler, A. et al. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 8, ...