FOXA1 (Forkhead Box A1) and FOXA2 (Forkhead Box A2) serve as pioneering transcription factors that build gene expression capacity and play a central role in biological processes, including organogenesis and differentiation, glycolipid metabolism, prolife
Programmed death-1 promotes contused skeletal muscle regeneration by regulating Treg cells and macrophages Article Open access 05 March 2021 Abbreviations MCH: Major histocompatibility complex APCs: antigen presenting cells CK: creatine phosphokinase ROS: reactive oxygen species DAMPs: damage Associa...
Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research ...
B-D Volcano plots illustrating differentially expressed genes (DEGs) in docetaxel-resistant prostate cancer cells: PCA3 (B), PCA7 (C), and PM154 (D). The x-axis shows the log2-fold change (log2FC), while the y-axis represents the negative log10 of the false discovery rate (FDR)-...
Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of aber
Cells co-cultured in single cell-specific media or non-optimal mixed media ratios showed increased cell death of either ECs or CCs (Fig. S1E). However, using the optimized mixed media condition, consisting of 50% EC medium and 50% CC medium, we found that 5.5% of cells expressed CD31 ...
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1). Glutamine deprivation in certain tumor cells can lead to growth arrest or even death [9,10,11,12,13], this phenomenon of tumor cells is one of known material addiction [7, 14]. The close relationship between glutamine and tumor cell growth, metastasis and invasion has been a subject...
Necroptosis contributes to ischemia-induced brain injury. Tumor necrosis factor (TNF) receptor associated factor 2 (TRAF2) has been reported to suppress necroptotic cell death under several pathological conditions. In this study, we investigated the role
[159]. Programmed cell death ligand 1 (PD-L1) is expressed and accumulates in senescent cells and is closely linked to the SASP. The use of PD-1 antibodies has been shown to reduce the number of p16-positive cells in the body and improve senescence-related phenotypes [160]. A variety ...