As developing tissues grow in size and undergo morphogenetic changes, their material properties may be altered. Such changes result from tension dynamics at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms controlling the ph
One-carbon-unit cycle A group of biochemical reactions that involve the transfer of the one-carbon groups between various molecules such as tetrahydrofolate, S-adenosylmethionine and vitamin B12. Ubiquinone A coenzyme that functions as an electron carrier in various biological processes, including the ...
Nutlin, a selective MDM2 inhibitor, is a negative regulator of the tumour-suppressor gene TP53, triggering apoptosis and cell cycle arrest exclusively in cancer cells retaining the wild-type TP53 form [70]. As depicted in Fig. 2C, seven of the 24 cell lines within this dataset harbour a ...
Tumor heterogeneity is a decisive factor for drug resistance The biology of normal cell transformation into cancer cells has been explained at the genetic/epigenetic and proteomic levels. However, reasons (usually random) for cancer initiation, development, and progression are not fixed and rather can...
If the reduced gene expression translates into reduced carbon flux into the TCA cycle and glyoxylate shunt, then the observed transcriptional changes are a first indicator that CoA-ester metabolism is possible disrupted. Fig. 5 Transcriptomic and proteomic profiling of the wild type S. rimosus ATCC...
pathways [67]. In both cases, host-mediated RNA editing ultimately affects the viral life cycle, host adaptation, or to some extent the evolutionary direction of the virus [22,135]. RNA editing in viruses has dual effects. In some cases, it helps the evade the host’s immune system and...
FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell proliferation, self-renewal, and tumorigenesis. In most human cancers, FOXM1 is overexpressed,...
The Anaphase Promoting Complex or Cyclosome (APC/C) is the largest member of the ubiquitin ligase [E3] family. It plays a crucial role in the control of the cell cycle and cell proliferation by mediating the proteolysis of key components by the proteasom
Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors. Dev. Cell 41, 129–142.e6 (2017). CAS PubMed PubMed Central Google Scholar Azzarelli, R. et al. Multi-site neurogenin3 phosphorylation controls pancreatic endocrine differentiation. Dev. Cell...
Here, the anti-CRISPR protein, AcrIIA4, was fused with the N terminal region of human Cdt1 that is degraded specifically in S and G2, the phases of the cell cycle when homology-directed repair (HDR) is dominant. Co-expression of SpyCas9 and AcrIIA4-Cdt1 not only increases the ...