with a 24-hour cycle under homeostatic conditions. This rapid cycling is necessary for the intestinal renewal, yet renders these stem cells vulnerable to exogenous influences. On the other hand, the +4 LRCs are very slow cycling, almost quiescent, cells, which protects them from environmental st...
As developing tissues grow in size and undergo morphogenetic changes, their material properties may be altered. Such changes result from tension dynamics at cell contacts or cellular jamming. Yet, in many cases, the cellular mechanisms controlling the ph
Intra-tumour heterogeneity (ITH) presents a significant obstacle in formulating effective treatment strategies in clinical practice. Single-cell RNA sequencing (scRNA-seq) has evolved as a powerful instrument for probing ITH at the transcriptional level, offering an unparalleled opportunity for therapeutic...
mitochondrial homeostasis, epigenetic modification changes, senescence-associated secretory phenotype, telomere shortening, telomerase activity decrease, and stem cell depletion74,75. In response to these mechanisms of aging, many studies have proposed various potential therapeutic strategies, such as ...
BKM120-responsive mutant PIK3CA PDXs were further found to display loss of CDKN2A, which encodes the cell-cycle regulator p16, an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6) activity. When compared to single therapies, combined PI3K and CDK4/6 inhibition, resulted in enhanced anti...
Extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling is important for cell cycle progression, proliferation, and differentiation, and also contributes to carcinogenesis. ERK interventions have had seemingly paradoxical effects on stem cells. That is, the activation ...
The cells had a discharge capacity of (2.69±0.04) mA h cm−2 in the second C/10 cycle. Using the measured electrode area from Table 1, a capacity of (158.6±2.4) A h for the original prismatic hardcase cell can be determined, which is in good agreement with the measured cell ...
Since its inception in 2010, Henlius has built an integrated biopharmaceutical platform with core capabilities of high-efficiency and innovation embedded throughout the whole product life cycle including R&D, manufacturing and commercialization. It has establis...
and invasive cell morphology.173Elevated expression of CCND1 is also related to reduced overall survival and poor prognosis among patients with OSCC.174,175CCND1 deficiency inhibits the cyclin-dependent kinases CDK4 and CDK6, which are responsible for the cell cycle progression by dephosphorylating ...
7 had advanced pancreatic cancer and underwent 2 to 4 cycles of CAR-T cell therapy. The findings indicated that a patient with stage IV PDAC, who had numerous metastases prior to therapy, experienced a 40% decrease in tumor size after the initial cycle, and subsequent infusions of CAR-T c...