Sign in to download full-size image Fig. 18.1.Overview of the cell cycle. The cell cycle consists of four phases driven by the activities of cyclin-CDK complexes. As it proceeds in relatively discrete phases, the cell cycle can be arrested at specific times. Cell-cycle checkpoints are prese...
Sign in to download full-size image Fig. 8.1.The phases of the cell cycle. The cell cycle begins in the G1phase of a diploid cell (DNA content = 2N; N is the number of chromosomes). After DNA replication is completed in the S phase, the cell enters the G2phase and has twice the...
This collection showcases ground-breaking cell cycle papers and reviews, ranging from basic discoveries to clinical applications.
and analysis software constructs a histogram of the data, with peaks indicating the relative proportion of cells in different cell cycle phases. Narrower, sharper, well-separated histogram peaks are the goal because they give the clearest
1.6.U4 Interphase is a very active phase of the cell cycle with many processes occurring in the nucleus and cytoplasm. 间期是细胞周期中持续时间最长的时期,但是也视不同细胞类型而定,对生长很快的细胞来说,比如动物的胚胎或植物的根尖茎尖生长点(分生组织那块位置),间期大约24小时。对于不怎么分裂的细胞来...
Our data on cell cycle inhibitors suggested that the effect of cell cycle arrest on ferroptosis is independent of the arrested cell cycle phases (Fig.1a–c). To further examine this, we generatedCDK1-deficient cells (Fig.1n). Similar to treatment with colcemid or nocodazole,CDK1deficiency arre...
Cell Cycle Compartments and Checkpoints The consecutive progression through four distinct phases of the cell cycle called G1, S, G2, and M results in proliferation of eukaryotic cells (Fig. 84.2). DNA replication occurs during the S phase; chromosome separation (karyokinesis) takes place during...
proteins governing the cell cycle.Cyclinsdo not possess any inherentenzymatic activitybut can activate protein kinases, which in turn phosphorylate and activate other important proteins of the cell cycle. There are different types of cyclins produced at different phases in the cell cycle (Fig. 1.12)...
cell cycle progression, including Cdc2/Cdc28, Cdc25, and Wee1 protein kinases. If the mutants in a population lack the gene necessary for initiating or completing a particular cell cycle phase, that phase becomes restrictive, and it prevents the cell from proceeding to later phases. As each ...
(clone) cells. The cell cycle has two major phases: interphase and the mitotic phase ((Figure)). During interphase, the cell grows and DNA is replicated. During the mitotic phase, the replicated DNA and cytoplasmic contents are separated, and the cell cytoplasm is typically partitioned by a...