Key words Cell cycleAlzheimer’s diseaseDown’s syndromeUsing immunohistochemistry we have analysed the nuclear expression of cyclins A, B, D, and E in neurones in the hippocampi of control subjects and patients suffering from various neurodegenerative disorders including Alzheimer's disease (AD). ...
See how flow cytometry, immunofluorescence or immunohistochemistry can be used to easily determine the cell cycle status.
Cell cycle regulatory protein expression by immunohistochemical assay may have diagnostic utility in the distinction of uterine leiomyosarcoma from leiomyoma variants. p16, p21, p27, and p53 protein expression was evaluated by immunohistochemistry on 44 atypical leiomyomas (mean follow-up, 50.8 mo), 16...
Immunohistochemical expression of cell cycle proteins in multiple myelomaDespite advances in the basic understanding and deIlias Pessach... I Pessach - 《Leukemia & Lymphoma》 被引量: 0发表: 2015年 Expression of the cell-cycle-related proteins E2F-1, p53, mdm-2, p21waf-1, and Ki-67 in mul...
At present, no objective markers were developed for the evaluation of dysregulation of cell cycle. We analyzed cell proliferation activity in SK, KA, actinic keratosis (AK), BD, and SCC by using a novel method, immunohistochemistry-based Cell Cycle Detection (iCCD), which is a multiplex ...
We set three hypotheses: (1) the overall capacity of tubular regeneration after injury is largely overestimated; (2) cell cycle markers may not consistently represent cell division; (3) regeneration is limited to tubular progenitors and other TECs entering the cell cycle after AKI undergo endo...
To investigate the subtypes of monocytes and macrophages that are associated with tumor-related responses, we identified monocytes and macrophages with high expression of cell cycle markers MKI67 and TOP2A, indicating a cluster of proliferating myeloid cells (Supplementary Fig. 8d) that we termed MK...
Alpha and beta subunits of inhibin/Activin as sex cord-stromal differentiation markers. Int J Gynecol Pathol. 1997;16:263–71. 56. McCluggage WG. Recend advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol. 2000;53:327–34. 57. Zheng W, Senturk BZ, et...
Current status of tissue-based biomarkers in NSCLC Tumor-based biomarkers have been extensively investigated to guide the use of ICIs in NSCLC. Expression of PD-L1 in tumor biopsies, as assessed by immunohistochemistry, is an approved biomarker to guide treatment decisions and predict the likelihood...
(PC) cells. The anti-proliferative effect of anlotinib for three PC cell lines was validated using CCK-8, colony formation and EdU detection assays. Cell cycle, cell apoptosis, and reactive oxygen species (ROS) detection assays, a PC xenograft model and immunohistochemistry were performed to ...