The most significant differentially expressed category of genes related to biological function was G2/M transition of mitotic cell cycle, which may include important cell cycle checkpoint genes (Fig. 2B). Gene set enrichment analysis (GSEA) indicated that EZH2 knockdown differentially affected the ...
Almost all tumours are deficient in cell cycle regulation, and cell cycle failure can induce cancer by promoting cell proliferation34,35. Similar to other studies36, our experimental results also indicated that ADRB blockers can inhibit tumour cell growth and induce G1/S arrest. CyclinD1 is an...
Analysis of single-cell transcriptome data from NSCLC patients revealed that CD20 + CD22 + ADAM28 + BIR (ICI-responsive B cells) cells in TLSs predicted and contributed to the response to checkpoint immunotherapy [20]. Single-cell sequencing was applied to analyze the immune ...
(B)Pro-inflammatory Response,(C)Cell cycle and Apoptosis,D)Metabolism and Signalling pathway. HBMVEC were treated with either Media (M) or TGRL lipolysis products (TL) for 3 hr. Microarray analysis: (pooled n = 3 per
“G2M CHECKPOINT” and “E2F TARGETS” were downregulated in immune MSCs. Second, 13 and 19 statistically significant gene sets were filtered by a corrected p value ≤ 0.05 from progenitor proliferative MSCs and pericytes, respectively. The immune-related gene set “TNFA SIGNALING VIA NFKB...
including cell cycle-related regulatory proteins Cell division cycle 27 (CDC27) and Aurora kinase B (AURKB) (Fig.1Gand Fig. S3E,F). In addition, 301 proteins exhibited impaired interactions with R-loops after A3B-depletion because their protein amounts were markedly reduced (>2-fold change ...
18k Accesses 65 Citations 1 Altmetric Metrics details Abstract Background Inducible inactivation of a protein is a powerful approach for analysis of its function within cells. Fission yeast is a useful model for studying the fundamental mechanisms such as chromosome maintenance and cell cycle. However...
cell cycle; cyclins; nuclear tau; nucleolus; neurodegeneration; SH-SY5Y cell line; Alzheimer’s disease1. Introduction Cell cycle progression is a key event in cellular homeostasis. It consists of the G1, S, G2, and M stages whose correct alternation is regulated, at specific checkpoints, ...
The progression through the cell cycle phases is driven by cyclin-dependent kinases (CDKs) and cyclins as their regulatory subunits and is tightly controlled by defined checkpoints [1,2]. The activity of the cyclin-CDK complexes is regulated by members of the CDK-interacting protein/kinase ...
CELL cycleUBIQUITINATIONUBIQUITIN ligasesCELL physiologyDNA damageObjective: The centrosome is universally recognized as the microtubule organizing center of animal cells, but emerging evidence suggests that it has other important functions including primary cilia formation, DNA damag...