We found that patterns of cell cycle checkpoint deregulation were associated with the intrinsic molecular subtype of breast cancer cell lines. Specifically, the luminal B and basal-like cell lines harbored two molecularly distinct Gap 2/mitosis checkpoint defects (impairment of the decatenation Gap 2...
Twist1 participates in chromosomal and genomic instability and downregulates critical cell cycle checkpoint factors in colorectal cancer cells [25]. It was reported that Twist1 was involved in the metastasis of cancers that could induce EMT [26]. Furthermore, Twist1 was a well-known repressor of...
Analysis of single-cell transcriptome data from NSCLC patients revealed that CD20 + CD22 + ADAM28 + BIR (ICI-responsive B cells) cells in TLSs predicted and contributed to the response to checkpoint immunotherapy [20]. Single-cell sequencing was applied to analyze the immune ...
e, Signalling diagram of the G1 cell-cycle program, showing how inhibiting CDK4/6 activity with a small molecule inhibitor will prevent APC/CCDH1 inactivation. f, MCF10A cells expressing either empty vector or various EMI1 variants were treated with DMSO. Single-cell APC/C activity traces ...
promoter in response to HBx and facilitates hepatoma cell invasion and metastasis [33]. In the chronic myeloid leukemia K562 cell line, FOXM1 is transcriptionally dependent on STAT3 and crucial for its cell proliferation, cell cycle checkpoints and viability [32]. However, twist-related protein 1...
CheckpointBuild ChildWindow ChildWindowTemplate Choose ChooseTarget 類別 ClassCollection ClassDetails ClassFile ClassInternal ClassLibrary ClassMethodReference ClassMethodReferenceAmbiguous ClassMissing ClassPrivate ClassProtected ClassPublic ClassSealed ClassShortcut CleanData ClearBookmark ClearBreakpointGroup ClearC...
They can be induced by multiple DNA-damaging agents and stressful growth arrest conditions, such as IR and UV radiation, and play important roles in the control of cell cycle checkpoint, DNA repair processes, and signalling transduction. The protein encoded by this gene responds to environmental ...
3b). Moreover, the expression of CNN3 is associated with the activity of several immune-related pathways and the expression of immune checkpoint molecules [49] (Additional file 1: Supplementary Fig. 3c). In addition, functional enrichment analysis revealed that the PACSI-identified cells associated...
Proteins more abundant in SVEC cells (murine endothelial cells) were enriched in pathways, including “processing pre-mRNA”, “cell cycle”, or “G2/m checkpoints”. This suggests its proliferation, migration, or coalescing of the endothelial cells to form primitive vascular labyrinths during ...
For example, the BATF gene, expressed explicitly in HSCs (hematopoietic stem cells), limits the self-renewal and differentiation checkpoint, and the JUNB gene regulates HSC function43. In MEP cells (megakaryocyte-erythroid progenitor cells), the specifically expressed motifs include the GATA family ...