All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents...
This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in human cancer. These areas include the G1/S transition, where most cancer-related defects occur, the G2/M checkpoint and its activation in response to DNA dam...
Cell-cycle checkpoints and cancer. Nature 432, 316–323 (2004). CAS PubMed Google Scholar Kops, G. J., Weaver, B. A. & Cleveland, D. W. On the road to cancer: aneuploidy and the mitotic checkpoint. Nature Rev. Cancer 5, 773–785 (2005). CAS Google Scholar Malumbres, M. &...
Cell cycle checkpoints and cancer Cell cycle checkpoints and cancer 中西 真 Protein, nucleic acid and enzyme 54(4), 556-560, 2009-03 中西,真 - 《Protein, Nucleic Acid\\\&\\\enzyme》 被引量: 13发表: 2002年 Cell Cycle Checkpoints and Cancer Chemotherapy O‘Connor,PM,Fan,S,Pinedo,HM,...
2020年9月1日,来自宾夕法尼亚大学的Roger Greenberg课题组在Cell Reports杂志上发表题为“Cell cycle checkpoints cooperate to suppress DNA and RNA associated molecular pattern recognition and anti-tumor immune responses”的文章。 该工作是建立在Greenberg实验室以及其他研究小组前期工作的基础之上,在这些 前期工...
Therefore, mutations in checkpoint controls may predispose cells to cancer by causing genomic instability. In this review, I will focus on the potential roles of cell cycle checkpoints in the progression of malignancy. 展开 被引量: 122
Identify important checkpoints in cell division Explain how errors in cell division are related to cancer The length of the cell cycle is highly variable, even within the cells of a single organism. In humans, the frequency of cell turnover ranges from a few hours in early embryonic developmen...
纺锤体检查点( spindle checkpoint)就是通过调节Cdc20,来调节APC/C的活性。 如下图,未附着动粒微管的染色体动粒上吸附着有丝分裂检查点复合体(MCC)。MCC由BUB1、BUB3、BUBR1,MAD2L1、Cdc20等构成,导致APC/C的抑制和细胞周期停滞。在动粒附着动粒微管的情况下,MCC复合物被分解,Cdc20被释放,这导致APC/C活化。
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Kinases of the Aurora, Polo and Nek families participate in the centrosome cycle and modulate spindle function. Additional kinases such as Bub1, BubR1 and Mps1 regulate the spindle assembly checkpoint. It has been well established that misregulation of Cdks is one of the most frequent ...