Single-cell analysis reveals context-dependent, cell-level selection of mtDNA Anna V. Kotrys, Timothy J. Durham, Xiaoyan A. Guo, Venkata R. Vantaku, Sareh Parangi & Vamsi K. Mootha Nature volume 629, pages 458–466 (2024)Cite this article 26k Accesses 58 Altmetric Metrics det...
S2). By analyzing the R-loop interactors from previous reports [28, 29], we noticed the involvement of APOBEC family members such as APOBEC3A (A3A), APOBEC3C (A3C) and APOBEC3D (A3D) in a context-dependent manner. This result prompted us to hypothesize that A3B might also be linked...
ptotic death by degrading ferritin, lipid droplets, circadian proteins, and GPX4, respectively. Autophagy modulators (e.g., BECN1, STING1/TMEM173, CTSB, HMGB1, PEBP1, MTOR, AMPK, and DUSP1) also determine the ferroptotic response in a context-dependent manner. In this review, we provide...
YAP and TAZ are notable in their ability to change both cell fate and survival. Depending on the context, they can either maintain a stem or progenitor state or stimulate differentiation and morphogenesis. We consider cell fate and survival to be linked, as morphological and biochemical similaritie...
, 2004). It is therefore probable that BR also regulates cell elongation in the root, although whether this occurs in an auxin-dependent manner is not clear. Show moreView chapter Book series 2010, Current Topics in Developmental BiologyTom Bennett, Ben Scheres Chapter Cellular Morphogenesis in ...
Avni D, Biberman Y, Meyuhas O: The 5′ terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type-and sequence context-dependent manner. Nucleic Acids Res. 1997, 25 (5): 995-1001. 10.1093/nar/25.5.995. Article CAS Google Scholar Jefferies H, Reinhard C,...
AβO1–42干扰SST+中间神经元对CA1 PC近端树突的去抑制作用,从而削弱嵌套Gamma振荡诱导的尖峰时间依赖性LTP(timing-dependent LTP, tLTP),光遗传学激活PV+和SST+中间神经元可恢复Gamma振荡及Gamma振荡诱导的tLTP作用[50]。 在神经振荡...
[106]. Mechanistically, CP prevented NRF2 nuclear accumulation and promoted β-TrCP-dependent NRF2 degradation in a glucocorticoid receptor- and a glycogen synthase kinase 3 (GSK3)-dependent manner [106]. As a result, CP induced oxidative stress and strongly suppressed the anchorage-independent ...
Poly(U) motifs are recognized by many RBPs, and therefore function in a context-dependent manner21. To identify the most likely trans-factors interacting with the poly(U) sequences in translationally repressed mRNAs, we used information from the sequence context in which the poly(U) motifs are...
These cell types display context-dependent functionality and can adapt to different requirements over their lifetime, as dictated by their microenvironment. These new insights into stem cell regulation and fate specification could aid the development of therapies that exploit the regenerative capacity and...