The autophagy mediated by STING1 is a selective process that requires specific signals and regulators in a context-dependent manner (Fig. 2). After binding to cGAMP, STING1 leaves the ER and is transported to the ERGIC, which serves as a membrane source for autophagosome biogenesis21. STING1...
. FER also regulates plant immunity by interacting with RALF23 to modulate elf18-induced ROS production (Xiao et al. 2019). Additionally, FER enhances flg22-induced FLS2-BAK1 complex formation, making FER an interactor/context-dependent positive or a negative regulator of plant immunity. This i...
ptotic death by degrading ferritin, lipid droplets, circadian proteins, and GPX4, respectively. Autophagy modulators (e.g., BECN1, STING1/TMEM173, CTSB, HMGB1, PEBP1, MTOR, AMPK, and DUSP1) also determine the ferroptotic response in a context-dependent manner. In this review, we provide...
S2). By analyzing the R-loop interactors from previous reports [28, 29], we noticed the involvement of APOBEC family members such as APOBEC3A (A3A), APOBEC3C (A3C) and APOBEC3D (A3D) in a context-dependent manner. This result prompted us to hypothesize that A3B might also be linked...
This occurs without affecting the normal process of CRM1-dependent nuclear export, but is associated with decreased binding of CITED1 to p300. These findings indicate that the transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner. EXPERIMENTAL PROCEDURES ...
Avni D, Biberman Y, Meyuhas O: The 5′ terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type-and sequence context-dependent manner. Nucleic Acids Res. 1997, 25 (5): 995-1001. 10.1093/nar/25.5.995. Article CAS Google Scholar Jefferies H, Reinhard C,...
Transgelin is a poor prognostic factor associated with advanced colorectal cancer (CRC) stage promoting tumor growth and migration in a TGFbeta-dependent manner. Cell Death Dis. 2020;11:341. CAS PubMed PubMed Central Google Scholar Shaath H, Toor SM, Nair VS, Elkord E, Alajez NM. ...
are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few ...
The PD-L1 binding arm of MCLA-145 plays a dual role; enabling context-dependent activation of CD137 while also blocking interaction with PD-1 on T-cells. The monovalent anti-PD-L1 activity of MCLA-145 was evaluated in a PD-1 reporter assay and compared to the bivalent monoclonal antibody...
In animals, maternal diet and environment can influence the health of offspring. Whether and how maternal dietary choice impacts the nervous system across multiple generations is not well understood. Here we show that feeding Caenorhabditis elegans with