Although this result seems to contradict the enhancement of the rough eye phenotype caused by Pi3k expression, recent studies have shown that Pten over-expression induces apoptosis in a cell context-dependent manner even though Pten functions to alleviate the effect of Insulin/IGF signaling [46]. ...
Finally, we applied MeDuSA to deconvolute cell-state abundances in an expression quantitative trait locus (eQTL) dataset (that is, a cohort with both single nucleotide polymorphism (SNP) genotype and bulk RNA-seq data) for detecting cell-state-dependent eQTLs (csd-eQTLs). Note that csd-eQTL ma...
(Methods). We define cell cluster-ieQTLs as the interaction expression quantitative trait loci that modify gene expression levels with a cell cluster-dependent manner (Supplementary Fig.3a). For instance, in the arterial tissue samples from GTEx individuals with a higher G allele dosage (rs...
Wu (2024). "Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner." Cell Metabolism 36(2): 408-421.e405. (20240206,西安交通大学,吴岳,袁祖贻,于君)揭示...
Avni D, Biberman Y, Meyuhas O: The 5′ terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type-and sequence context-dependent manner. Nucleic Acids Res. 1997, 25 (5): 995-1001. 10.1093/nar/25.5.995. Article CAS Google Scholar Jefferies H, Reinhard C,...
are being explored to temporarily open the BBB in order to allow accumulation of therapeutics in the CNS. Undoubtedly, the major concern in field is whether it is possible to open the BBB in a meaningful way without causing negative consequences. In this context, we have also listed few ...
[106]. Mechanistically, CP prevented NRF2 nuclear accumulation and promoted β-TrCP-dependent NRF2 degradation in a glucocorticoid receptor- and a glycogen synthase kinase 3 (GSK3)-dependent manner [106]. As a result, CP induced oxidative stress and strongly suppressed the anchorage-independent ...
universal activity of sodium periodate on all RNAs, the Slic-seq method enriches inosine-containing RNAs and accurately identifies editing sites [18]. REDIportal provides a comprehensive overview of human RNA editing, implements a gene view module to display individual events in genetic context, and ...
contexts, on the other hand, diminished the neurons’ ability to differentiate among semantic representations. Therefore, rather than simply responding to words as fixed stored memory representations, these neurons seemed to adaptively represent word meanings in a context-dependent manner during natural ...
The autophagy mediated by STING1 is a selective process that requires specific signals and regulators in a context-dependent manner (Fig. 2). After binding to cGAMP, STING1 leaves the ER and is transported to the ERGIC, which serves as a membrane source for autophagosome biogenesis21. STING1...