Fat is composed of cells with clear cytoplasm and peripherally located nuclei. The majority of the cytoplasm consists of a single vacuole of fat, which appears empty because the fat dissolves during histologic processing. There is typically very little extracellular matrix in normal adipose tissue. ...
and successfully established a causal relationship between pathogenesis of ageing-related diseases and cell senescence. Take atherosclerosis as an example, we have known that plaques composed of fat and protein gradually accumulate on the inner arterial wall, which is prone to cause coronary atherosclerot...
Tissues contain differentiated parenchymal cells that perform the primary functions of an organ (e.g.epithelial cells in skin, adipocytes in fat, neurons in brain). Although long overlooked, the stromal compartment regulates and supports parenchymal cells, building the shape and compartmentalization of ...
Free fatty acid release from fat cells, obtained from epididymal adipose tissue of rats of different sizes, was found to be dependent on the cell surface area, regardless of the age of the animals. The same result was found with cells of different sizes from the same animal. These results,...
J. et al. Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not with insulin resistance. Mol. Cell Biol...
and only substances with a molecular weight of less than 1.5 kDa are allowed to pass through [29]. Therefore, mitochondria obviously cannot be directly trafficked intercellular through GJCs. A recent study by Alarcon-Martinez revealed that a structure composed of TNTs and one distal-side CX43 ...
Finally, xenograft studies have shown that co-injection of tumour-associated (Hs578Bst) or integrinβ6-positive (β6-1089) myoepithelial cells, together with cancer cells, can potentiate tumour growth in the mammary fat pad, further supporting their role in disease progression [46,48]. Despite...
Mesenchymal stem cells (MSCs)are stem cells found in bone marrow, from where they can generate bone, cartilage, fat, and fibrous connective tissue. They are the non-hematopoietic, structural components of bone marrow that support hematopoiesis by providing extracellular matrix components, cytokines, ...
A mesh structure just inside the nuclear membrane that is composed of lamins and lamin-associated proteins. Nuclear speckles Also known as splicing speckles, these are nuclear domains enriched in pre-mRNA splicing factors and located in interchromatin regions of the nucleoplasm. Superenhancers Genomic...
In vivo microscopic images of fat tissue of a rat at back reflectance from a few millimeters of an intact abdominal fat layer using a CMOS camera: a white light source (a); green LED 517 nm (b); He–Ne laser 632.8 nm (c); the light breeze on the shallow seawater on a sunny day...