on to participate in the repairs needed to restore tissues and functions. There are many peer-reviewed publications that provide examples of how the cells involved in this process can be enhanced by combined provision of the cellular, native scaffolding, and biologically active components (Box 3)....
Plasma insulin levels depend on the absolute number of insulin secretingβ-cells (i.e.,β-cell mass) and the functional status of each of these cells (i.e.,β-cell function). Hereby, deficiency in either dynamics ofβ-cell mass or function, or both, results in insulin insufficiency and ...
In the interaction system of stem cells and their stem cell niches, the regional characteristics of stem cell niches determine the specific functions of stem cells. Introducing the plate tectonics in geology mainly reflects the stable static components of the stem cell niches. In the same plate, ...
When cilia go bad: cilia defects and ciliopathies. Nature Rev. Mol. Cell Biol. 8, 880–893 (2007). Article CAS Google Scholar Gibbons, I. R. Studies on the protein components of cilia from Tetrahymena pyriformis. Proc. Natl Acad. Sci. USA 50, 1002–1010 (1963). Article CAS Pub...
The individual components of the model are depicted in descending order of their association with poor survival inFigure 5D.MYCgenetic alterations combined withMYCexpression defined the subset with the least favorable prognosis in DLBCLs, while GCB DLBCLs withCD70alterations had the most favorable prog...
In multicellular organisms, cellular communication facilitates the coordination of multiple cells, enabling the formation of tissues, organs, and the fulfillment of diverse biological functions. Unveiling the CCC network through quantifying ligand-receptor (L-R) pairs in single-cell transcriptomics represents...
a, Structural components of CD97. Triangles indicate EGF domains. The ten amino acids (419–428) following the GPS are indicated.b, Representative histogram plot of CD97 on MZ and follicular (FO) B cells; ISO, isotype control.c,d, Flow cytometry profiles (c) and frequencies of MZ B cel...
T cell function and fate can be influenced by several metabolites: in some cases, acting through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through post-translational modification of lysines in important targets. We show here that glutarate, a product of amino acid ...
The distinct biological functions, the subtype-specific distribution, the potential cells of origin and the interrelation of consensus cancer cell states were systematically elucidated and validated in multiple independent datasets. We further uncovered the internal regulons and external cell components in ...
Figure 1. Distribution of bone matrix components. 2.2.1. Organic Component of the Bone Matrix Collagen fibers are found in all types of connective tissue and are made up of the protein collagen. These fibers are very tensile (an elongation of 10 to 20% may result in a fiber break) and...