2024年3月28日,Cell发表了题为“Embracing cancer complexity: Hallmarks of systemic disease”一文,探讨了肿瘤作为系统性疾病的复杂性,包括肿瘤启动和促进、微环境、免疫、衰老、代谢、肥胖、恶病质、昼夜节律、神经系统、血栓形成和微生物组...
2024年是p53蛋白被发现的45周年。Moshe Oren和Carol Prives教授在Cell杂志上发表了题为“p53: A tale of complexity and context”的文章。 该综述全方位地总结了p53的发现、结构、功能、调节、在生理病理过程中的作用、治疗靶点潜力...
AI代码解释 AnnData objectwithn_obs × n_vars=4785×34617obs:'orig.ident','nCount_RNA','nFeature_RNA','sample_id','sample_type','organism','donor','sex','age_days','eye_condition','genotype','driver_lines','reporter_lines','brain_hemisphere','brain_region','brain_subregion','injec...
作者在该研究中通过大量的组学数据和生物化学、分子生物学实验，研究人员成功鉴定出Ataxin2和Ataxin2L这两个核心蛋白作为调控节律蛋白翻译的关键因子。这两个蛋白都定位于细胞质，并具有稳定折叠的RNA结合结构域（如Lsm结构域）和大量固有无序化的低复杂度序列结构域(low-complexity sequence domain, LCD)。研究人员的实...
6.低复杂性结构域(Low-complexity domain, LCD):一种富含或仅由少数类型氨基酸组成的蛋白质片段。这些片段的组合通常遵循简单模式,如串联重复,并且与分子的快速进化速率相关。 7.物质状态(Material state):物质可以产生的物质状态或相有四种:气体、液体、固体和等离子体。
whereas fibroblasts and myeloid cells undergo dramatic diversification. Endothelial cells and pericytes display global transcriptional shifts without changes in cell complexity. Collectively, our findings provide a comprehensive analysis of the cellular and transcriptomic landscape of human heart failure, identify...
他们发现FUS的LCD结构域（Low complexity sequence domain）能与TAZ的CC结构域（Coiled-coil domain）直接互作，并受上游DNA-PK介导的LCD磷酸化调控。通过识别CC结构域，FUS能够显著地限制CC 结构域对TAZ凝聚体形成的驱动作用，并且该过程不受上游Hippo信号通路的影响。犹如世上万物皆有始终，细胞内无膜凝聚体的稳态...
Baruni J, Luo L. Illuminating complexity in serotonin neurons of the dorsal raphe nucleus. Neuron. 2022 Aug 17;110(16):2519-2521. doi: 10.1016/j.neuron.2022.07.013. Xu J, Liu Y, Li H, Tarashansky AJ, Kalicki CH, Hung RJ, Hu Y, Comjean A, Kolluru SS, Wang B, Quake SR, Luo...
Here we explore in detail the complexity of NK cell biology in humans and highlight the role of these cells in cancer immunity. We also analyse the harnessing of NK cell immunity through immune checkpoint inhibitors, NK cell engagers, and infusions of preactivated or genetically modified, ...
Parkinson’s disease (PD) coincides with a dramatic loss of dopaminergic neurons within the substantia nigra. A key player in the loss of dopaminergic neurons is oxidative stress. Dopamine (DA) metabolism itself is strongly linked to oxidative stress as