虽然有个别例外情况(比如自回归神经网络Autoregressive networks),但多数深度学习算法都是这样工作的,比如感知器(perceptron)、卷积神经网络(Convolutional Neural Network,CNN)以及循环神经网络(Recurrent Neural Network, RNN)。 生物神经元和深度学习的概念大不相同。 生物神经元并不会保持连续信号,而是产生动作电位,或者依...
2024年12月11日,西湖大学吴建平及闫浈共同通讯在Nature在线发表题为“Structure and assembly of the dystrophin glycoprotein complex”的研究论文,该研究从小鼠骨骼肌中分离了天然DGC,获得了其高分辨率结构。该研究揭示了一个明显不同的DGC组装模型结构。 具体来说,在细胞外,β-、γ-和δ-sarcoglycans共同折叠形成一...
bodies and a network of branched protrusions with frequent constrictions. The cell envelope consists of a single membrane and complex surface structures. A long-range cytoskeleton extends throughout the cell bodies, protrusions and constrictions. The twisted double-stranded architecture of the filaments...
We categorized these datasets into three classes: (1) large datasets with a simple cell composition, such as Baron Human, Lake, and Zillions; (2) small datasets with a simple cell background, such as Muraro, Baron Mouse, Deng, etc.; and (3) datasets with complex cell structures, for ...
We show that this network captures biologically-meaningful pathways, cell-type specific modules, and connectivity patterns characteristic of complex networks. We develop a model that uses this network to discriminate biological vs. technical zeros, by exploiting each gene's local neighborhood. For non-...
This matrix provides a scaffold for the cells to grow and form complex structures, such as neural networks, spheroids, or organoids, that more closely resemble the tissue architecture of the nervous system. A 3D environment allows cells to interact with each other in a way that more closely ...
The inference of cell-cell communication (CCC) is crucial for a better understanding of complex cellular behavior and regulatory mechanisms in biological systems. However, current computational methods still encounter substantial constraints in inferring spatially resolved CCC at the single-cell level, ...
Single-cell RNA-sequencing (scRNA-Seq) is widely used to reveal the heterogeneity and dynamics of tissues, organisms, and complex diseases, but its analyses still suffer from multiple grand challenges, including the sequencing sparsity and complex differential patterns in gene expression. We introduce...
As biological processes are complex and interactive, there are subtle relationships between pathways, which are calculated by Q and K and referred as attention score (A). It is noteworthy that the attention scores between CLS and pathway tokens mean the importance of the latter to the ...
A deeper understanding of genetic regulation and functional mechanisms underlying genetic associations with complex traits and diseases is impeded by cellular heterogeneity and linkage disequilibrium. To address these limits, we introduce Huatuo, a framework to decode genetic variation of gene regulation at...