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For example, in this analysis a cell from every cell type was required to be in the initial annotated set, which is virtually never the case on real data since the cell types are not known in advance and it is unlikely to occur by chance due to cell type class imbalance, which is ...
Stromal cells belong to a class of heterogeneous cells that can fulfill a broad area of extremely important roles in both health as well as disease. They play a major character during regeneration, development, immune responses, tissue injury, cancer, and other pathologies by offering various biolo...
E Hierarchy diagram: “Source” represents the cell class that sends the signal, “target” represents the cell class that receives the signal, and the circle color represents the cell class. F The signaling pathway relationship to the bubble diagram shows significant interactions between the ligand...
actively direct the differentiation of cells around them. Answers to these questions should provide important clues to the basic biology and potential of MSCs. That is, if these cells are intended for regeneration, the undifferentiated state is thus a dormant state until they are called upon to ...
(KNOX). TFs from the Homeodomain-leucine Zipper class III (HD-ZIP III) family are also positioned high in the regulatory hierarchy and are important for cell differentiation (Du and Wang,2015). HD-ZIP III expression is regulated by microRNAs miR165/166, ensuring proper vasculature patterning (...
Of the 17 non-carcinogens tested in both in vitro mammalian cell tests, 9 (41%) are in this structural class. With the exception of 4-nitro-o-phenylenediamine and HC Blue 2, the chemicals in this class of non-carcinogens were positive in all in vitro mammalian cell tests. The ...
Diabetes, a group of metabolic disorders, constitutes an important global health problem. Diabetes and its complications place a heavy financial strain on both patients and the global healthcare establishment. The lack of effective treatments contributes
For a multi-class classification with K cell types, the cell type label Cref is one-hot encoded to a binary matrix with dimension N × K. The one-hot encoding labels the corresponding class as 1 and all others as 0 for each cell. The last layer of MLP is connected to a ...
Role of T cell subsets in lethal graft-versus-host disease (GVHD) directed to class I versus class II H-2 differences. I. L3T4+ cells can either augment or retard GVHD elicited by Lyt-2+ cells in class I different hosts. J Exp Med. 1988;167:556–69. Article CAS PubMed Google ...