In addition to qualitative analyses with confocal and light-sheet microscopy, quantitative analytical tools will be also employed such as traction force microscopy (TFM), monolayer stress microscopy (MSM), and cellular force interference (CellFIT). Finally, the use of mice models will allow for con...
Human induced pluripotent stem cells free of vector and transgene sequences. Science 324, 797–801 (2009). Article CAS PubMed PubMed Central Google Scholar Tanabe, K., Nakamura, M., Narita, M., Takahashi, K. & Yamanaka, S. Maturation, not initiation, is the major roadblock during ...
Single-cell RNA sequencing (scRNA-seq) has revealed an unprecedented degree of immune cell diversity. However, consistent definition of cell subtypes and cell states across studies and diseases remains a major challenge. Here we generate reference T cell atlases for cancer and viral infection by mul...
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Who we are:We are an international and dynamic research group, using automated systems to investigate cellular mechanisms underlying endosomal receptor trafficking and how alterations in this process relate to major human diseases, especially hypercholesterolemia. To achieve this goal, we combine open-sour...
(Zostera) Lukas Pfeifer1, Gijs van Erven2, Elizabeth A. Sinclair3, Carlos M. Duarte4, Mirjam A. Kabel2 and Birgit Classen1* Abstract Background: The polyphyletic group of seagrasses shows an evolutionary history from early monocotyledonous land plants to ...
Molecular profiling of these tumors has revealed other potential targets for therapy, including high tumor mutational burden andPD-L1 amplification, which predict response to immune checkpoint blockade (PD-1 and PD-L1 inhibitors). An illustrative patient with a giant, advanced, unresectable basal cell...
This may have relevance to the development of renal cell carcinoma (RCC), where mutations of the von Hippel-Lindau (VHL) gene are major risk factors for the development of familial and sporadic RCC. VHL mutations up-regulate and stabilize HIF, which in turn activates many downstream molecules,...
Transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMPs) utilize parallel and related signaling pathways, however the interaction between these pathways in bone remains unclear. TGF-β inhibition has been previously reported to promo
Who we are:We are an international and dynamic research group, using automated systems to investigate cellular mechanisms underlying endosomal receptor trafficking and how alterations in this process relate to major human diseases, especially hypercholesterolemia. To achieve this goal, we combine open-sour...