The role of XCR1 and its ligand XCL1 in antigen cross-presentation by murine and human dendritic cells. Front. Immunol. 3, 14 (2012). Article PubMed PubMed Central Google Scholar Meyer, M. A. et al. Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to ...
By default, BANKSY uses the Leiden community detection algorithm33 for its speed and scalability, although other methods (Louvain, model-based clustering, and k-means) are also provided as options. Fig. 1: BANKSY’s neighborhood-based feature augmentation strategy for clustering. a, The original ...
Another extracellular structural section known as the hinge region connects the scFv to the transmembrane structure and allows the antigen-binding structural section to overcome the spatial site barrier to reach the targeting epitope [9]. The intracellular domain has a direct impact on the CAR-...
The cytidine deaminase, Apolipoprotein B mRNA editing enzyme catalytic subunit 3B (APOBEC3B, herein termed A3B), is a critical mutation driver that induces genomic instability in cancer by catalyzing cytosine-to-thymine (C-to-T) conversion and promoting
Clec9A shows great promise as a target for immune modulation, and its restricted expression is an advantage for this application. Targeting Ags to mClec9A on DCs via a single injection of anti-mClec9A mAb gave a marked enhancement of the normally poor mouse response to rat Ig, and good enhan...
structures makes it a potential ADAR substrate, and A-to-I editing can influence the stability and function of lncRNA by altering the structure of lncRNA and its interaction with miRNA [53]. This suggests a connection between RNA editing and gene silencing in terms of impeding gene regulation...
rimosus HP126, a previously obtained mutagenized derivative, and its parent strain S. rimosus ATCC 10970. To this end, we placed both strains in submerged batch cultures using a complex starch-containing medium similar to the industrial media used for decades to manufacture oxytetracycline [22]...
Class 1 is divided into type I, III, and IV, and class 2 is divided into type II, V, and VI. Each type has its signature Cas protein. Cas9 belongs to type II of class 1 CRISPR-Cas system and is derived from S. pyogenes (SpCas9) [16]. Cas9 coupling to target sequence requires...
The aster grows and transforms into a bipolar spindle5. The physiological relevance of chromosome clustering in human oocytes and its underlying mechanism are unknown. Chromosomes in starfish and Xenopus oocytes are also transported before spindle assembly. The nuclei of these oocytes are over two ...
Arginine has shown promising results in enhancing liver function by modulating nitric oxide signaling that impacts vascular health and hepatic circulation8, 9. Its effect is also observed on the urea cycle to drive fatty acid oxidation10 and contribute to ammonia detoxification11. Arginine ...