aIt shows how DNA tells the cell to built its parts, the words in the DNA map, but we still do not understand what they all do. 它显示怎么脱氧核糖核酸在脱氧核糖核酸地图告诉细胞对建立了它的零件,词,但我们仍然不了解什么他们全都。[translate]...
Therefore, with the date of origin of a cell-in-cell-related gene we do not imply that this was the date of origin of its function, but the date of origin of that gene sequence. For building Fig. 1, we have used the NCBI Taxonomy22 and the TimeTree52,53 databases. Neither of ...
To understand what this means, consider the following: When a mutation gives a cancer cell a growth advantage, it can make more copies of itself than a normal cell can — and its offspring can outperform their noncancerous counterparts in the competition for resources. Later, a second mutation...
In this review, we concretely describe the characteristics of the SASP and its regulation mechanisms. Importantly, we provide novel perspectives on how the SASP can promote atherosclerosis. The SASP from different types of senescent cells have vital roles in atherosclerosis progression. As a significant...
Once a cancer has begun its unruly growth it will pick up more and more mutations: the cancer genome project at the Sanger Institute, outside Cambridge in England, has found that cancers can have as few as ten mutations or as many as a few hundred. Though all the cells in the cancer ...
Although the function of rab1 is still not fully understood, several lines of evidence describe rab1 and its yeast homolog Ypt1p GTPase as a major component in a pro- tein complex responsible for directing vesicular traffic between the ER and the Golgi apparatus [7-13]. In the past, ...
In droplet-based single-cell and single-nucleus RNA-seq experiments, not all reads associated with one cell barcode originate from the encapsulated cell. Such background noise is attributed to spillage from cell-free ambient RNA or barcode swapping event
L. The tumor microenvironment and its role in promoting tumor growth. Oncogene 27, 5904–5912 (2008). Article CAS PubMed PubMed Central Google Scholar Fan, J., Slowikowski, K. & Zhang, F. Single-cell transcriptomics in cancer: computational challenges and opportunities. Exp. Mol. Med. ...
3d,e). Therefore, F-Cell specification is a post-mitotic event and displays plasticity before the activation of neur expression. The association of the F-Cell with the bristle, and its proximity to the socket and shaft cells (Fig. 1e and Extended Data Fig. 2), suggests that F-Cell ...
无独有偶,9月21日,来自美国康奈尔大学的于海源课题组在Nature Genetics上发表了题为Transcription imparts architecture, function and logic to enhancer units的研究,报道了基于大规模序列活性筛选的对增强子的转录功能及序列特征的详细分析,经由另一条途径揭示了增强子单元的转录本质。