Understanding the genetic and epigenetic basis of cell identity and plasticity in regeneration and tumorigenesis Research Our team Publications News Congratulations! Congratulations to Dr. Tata for winning one of only two 2022 ISRB Rising Star Awards. This award is given to early career researchers cha...
Moreover, genetic inhibition of Wnt secretion in perictye-like stromal cells or stromal cells more broadly demonstrates their essential roles in gastrointestinal regeneration and development, respectively, highlighting a redundancy in gastrointestinal stem cell niches....
Laboratory assistants in biology and medicine play a central role in the operation of laboratories in hospitals, research institutes, and industries. Their daily work routine is characterized by dealing with molecular structures/chemical substances (i.e. biochemistry) as well as cell cultures (i.e....
scSpace co-embeds these two types of data into a shared latent space and extracts the shared latent features. Using the characteristic matrix from ST data, scSpace trains a multi-layer perceptron model with spatial coordinates as the outcome and latent features ...
Ultimately, this model has the potential to significantly improve survival rates and treatment outcomes for patients with BC. The pathogenesis of BC is a complex process influenced by various genetic and environmental factors [38]. When integrating bulk-RNA seq and scRNA-Seq screening signatures, ...
Ganem NJ, Storchova Z, Pellman D (2007) Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 17:157–162 Article CAS PubMed Google Scholar Gattegno T, Mittal, A, Valansi, C et al (2007) Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans. Mol Biol ...
(AD). While the recent surge of genetic evidence linking microglia to neurodegenerative diseases [5,6,7] has spurred increased research, functional studies in human microglia remains challenging due to the difficulties associated with obtaining them from human brain and spinal cord autopsy and surgery...
Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analyses ArticleOpen access22 November 2024 21 December 2023 Main Ovarian aging has garnered substantial attention in recent years due to a large proportion of female humans choosing to delay childbearing1, which of...
The genetic and epigenetic alterations in cell-free DNA (cfDNA) are barcoded, amplified and stored in the Mutation Capsule library, which can support 10 tests without sacrificing sensitivity like dividing a single cfDNA sample into multiple reactions. In each test, different panels of biomarkers suc...
The cause of theplasma cell dyscrasiasis unknown. Although there is no known hereditary predisposition, certain genetic abnormalities have been identified as associated with the plasma cell dyscrasias. For example, loss of a portion ofchromosome 13is associated with a poor prognosis. ...