Using the CHARMM-GUI membrane builder60,61, we generated 12.5 ×12.5 nm2patches of these model membranes, energy minimized them with a steepest descent algorithm until the largest force acting on any atom was below 1000 kJ mol−1and subsequently equilibrated them following the CHARMM-GU...
NO is also associated with some of the most important immune pathologies, including rheumatoid arthritis, diabetes, systemic lupus erythematosus and septic shock. NO is derived from the guanidino nitrogen atom(s) and molecular oxygen in a reaction catalysed by three forms of NO synthase (NOS). ...
Designing both optical potential and chemical potential of atoms symmetrically in one dimensional space, polarization of atom population in the double-trap system can be created due to the difference of two light beams. The polarization of atom number distribution induces net current of atoms and ...
[48]. The closest distance between the periodic box and atom was set as 12 Å, and the time step was set to 2 fs. Before simulation, hydrogen atoms were added, and any water molecules that did not interact with the protein were removed, and 20 mM sodium chloride was added to ...
In all cases, we placed the PEBP1 molecule 15 Å away (closest atom-atom distance) from 15LOX2 and examined its diffusion and binding to 15LOX2. Six out of eight runs conducted in the absence of Fer-1 led to a 15LOX2/PEBP1 functional complex (Fig. 2d, left panel, Supplementary ...
Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP, the A2A receptor (A2AR) and phosphodiesterase 10A (PDE10A), are differentially co-expressed in various typ
We report an experimental investigation of coherent population trapping in specially selected Zeeman levels of the sodium atom, performed under high buffer... JH Xu,G Alzetta - 《Physics Letters A》 被引量: 16发表: 1998年 Characterizing passive coherent population trapping resonance in a cesium va...
Under physiological conditions, ordered proteins are known to possess unique three-dimensional (3D) structures, in which each atom of the polypeptide chain has a unique position in space. These structures are determined by a vast number of intrachain non-covalent side chain-side chain, side chain...
The term “Differential Expression” has been extensively used in gene expression studies including microarrays [19], RNA-seq [20], and scRNA-seq [16]. The basic difference of DEA for scRNA-seq, compared with other studies, is that it is used to detect bio-markers across the cell types,...
and those between the 4-bromobenzyl motif in the ligand and the alkyl chains of I84, L79, and E82 in protein (Fig.2c). Additionally, theN-atom connected to the difluorobenzyl group forms a hydrogen bond with the side chain of Y118 (Fig.2c). Likewise, anotherN-atom that is connected...