Inhibitory interneurons located in the molecular layer of the cerebellum. Basket cells are located close to Purkinje cells and are spread out horizontally. Active zone A portion of the presynaptic membrane that faces the postsynaptic density across the synaptic cleft. It constitutes the site of synapt...
DMTN is a relay nucleus that is innervated by tufted-like cells of the OB68 and is located at the interface between the pallium and OB, of which it constitutes the caudal-most portion. Like the OB, the DMTN displays a layered structure with outer glutamatergic neurons, which share the ...
Binding of Hh ligands, relieves the inhibitory effect of their Patched (PTCH) transmembrane receptors on Smoothened (SMO), which is also located in the cell membrane. Subsequently, the signaling cascade initiated by SMO leads to activation and nuclear localization of GLI transcription factors, which...
Tumor cells sometimes invaded the preexistinginterlobular ductsand formed a front with nonneoplastic cells in the same ducts, presenting an intraductalextension in three cases. The CgA-IR cells were located at the base, lay between tumor cells, or were on the luminal side. In one of the thre...
There have also been many exciting discoveries regarding the cellular constituents of MTs in recent years. RNSCs located in the lower tubules and ureters of the MTs are essential for the regeneration of injured renal tissue comprising stellate cells (SCs), principal cells (PCs) and renalcytes (...
The LRRTM proteins are a group of brain-enriched type-I transmembrane proteins that contain extracellular leucine-rich repeats and a short cytoplasmic tail. Four known LRRTMs are recognized (LRRTM 1–4) and are mainly located at excitatory synapses. The LRRTM family is expressed in both develop...
ITM2C is one of the genes highly expressed in HC1 cells (Figure 3K), and in situ hybridization revealed that ITM2C mRNA is expressed in a narrow strip of hair cells, which we call “superior tall hair cells” because they are located at the edge of the superior cartilaginous plate (...
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-off between the activity and specificity in human TFs encoded as submaximal dispersion of aromati...
If this is the case, it may be possible to observe different combinations of TF motifs – a motif grammar – located at the TF binding sites in different cell types. In this study, we develop a bioinformatics method to systematically identify DNA motifs in TF binding sites across multiple ...
(red stars) that interact with the membrane-proximal domain (MPD) of ADAM17, The extracellular domains of ADAM17 on the cell surface are marked as follows: 1: Metalloprotease domain, 2: Disintegrin domain, 3: MPD, CANDIS is stained blue and is located between the MPD and the plasma ...