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4g). Accordingly, blocking Notch activation using the γ-secretase inhibitor DBZ reduced growth of organoids (Fig. 4h and Extended Data Fig. 6d), which failed to differentiate and stratify (Fig. 4i). Thus, it appears that the ectocervical stem cells act as a source of Notch signals, ...
This newly identified miR-886-3p-PLK1/TGF-尾1 nexus that modulates SCLC aggression suggests that both loss of miR-886-3p expression and hypermethylation of the miR-886 promoter are the promising indicators for poor outcome of as well as new therapeutic targets for SCLC.Cancer Research...
(Supplementary Fig.3d), indicating the conservation of this mechanism in ECs from different vascular beds. On the other hand, silencing ofEFNB2in HUAECs, which express much higher levels of the ligand than HUVECs (Supplementary Fig.3e), does not lead to upregulation ofEPHB4(Supplementary Fig...
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(channel)value 【通道值】 10/8 bit black point【 黑点参数】 10/8 bit white point 【白点参数】 3D glasses 【三维眼镜】 3D motion 【3D过渡】 3D view 【三维查看】 4 color gradient 【四色渐变】 5.1 mixdown type【 5.1混音类型】 abort capture on dropped frames 【丢失帧则中断采集】 absorption...
To discover genes sharing similar regulatory logic, we clustered genes by their optimal model coefficients using correlation as the distance metric (see STAR Methods) and found that sets of genes share the same combinatorial regulation profile (Figure 3D). For example, Lefty1, Lefty2, and Pycr2...
In Vivo DAPT and DBZ For drug treatments, RPM mice were enrolled in treatment at the earliest signs of tumor burden determined by microCT imaging (typically 4-6 weeks post-Cre, 6-10% tumor burden). RPM mice (n = 8) were given freshly prepared DAPT (GSI-IX) γ-secretase inhibitor (20...
As the EBV lytic cycle promotes the death of infected cells, we studied the possible pro-apoptotic effect of GSI treatment on EBV-infected cells. Treatment of 4134/TERT+ cells for 5 days with 5 μM of CompE or 0.5 μM of DBZ induced an increase in the number of apoptotic cells ...