TightandAdherens JunctionSignaling JenniferL.HarderandBenMargolis DepartmentsofInternalMedicineandBiologicalChemistry,UniversityofMichigan,AnnArbor,MI48109,USA Signalingpathwaysconverginguponandemanatingromadherensjunctions(AJs)andtightjunctions(TJs)aectmanycellularunctions,includingcytoskeletal dynamics,polarizedvesicletraf...
Furthermore, we show that the cardiac adherens junction (AJ) plays a direct role as a molecular regulator of CPC structural patterning. Collectively, these findings have uncovered a cellular-mechanics-based model for CPC developmental maturation that defines specific cytoarchitectural features that ...
Here, we report that inSPECC1L-knockdown cultured cells, staining of canonical adherens junction (AJ) components, β-catenin and E-cadherin, was increased, and electron micrographs revealed an apico-basal diffusion of AJs. To understand the role of SPECC1L in craniofacial morphogenesis, we ...
Adherens junction(s) ARVCF: Armadillo repeat gene deleted in velo-cardio-facial syndrome ASA: Alter super alterum CDH: Cadherin CK(s): Cytokeratin(s) CLC: Cumulative literature collection ECM: Extracellular matrix ESM: Electronic supplementary material IF: Intermediate-sized filament LSMC...
SPP induces the Gi/mitogen-activated protein kinase/cell survival pathway and the small GTPase Rho- and Rac-coupled adherens junction assembly. Both EDG-1- and EDG-3-regulated signaling pathways are required for endothelial cell morphogenesis into capillary-like networks. Indeed, SPP synergized with...
SPECC1L-kd U2OS cells show altered expression of adherens junction markers. (A–H)Increased F-actin staining in kd cells at 48 hours post-confluency (T6;A,B). Altered F-actin associated Myosin IIb staining (C,D). Smooth pattern of β-catenin and E-cadherin membrane staining in control...
Expert-reviewed signaling pathway providing a current overview of adherens junction dynamics and links to products by Cell Signaling Technology.
Adherens junctions are one of the three cell-cell junctions that are essential to the establishment and maintenance of the cellular architecture of all epithelial tissues. Surprisingly, we found that downregulation of FLCN leads to increased cell-cell adhesion in functional cell-based assays and ...
www.nature.com/scientificreports OPEN received: 25 June 2015 accepted: 05 November 2015 Published: 20 January 2016 SPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delamination Nathan R. Wilson1, Adam J. Olm-Shipman1, Diana S....