Ceftriaxone is excreted unchanged both by the kidney and by the liver, the proportion excreted by the kidney being higher in those aged less than 6 years than in older persons. Renal clearance of total ceftriaxone varied with both dose and time, but that of the free ceftriaxone fraction did ...
coli, Klebsiella†). In neonates, some experts recommend continuing treatment for 2 weeks beyond first sterile CSF culture or for at least 3 weeks, whichever is longer.Healthcare-associated Ventriculitis and Meningitis IV 100 mg/kg daily as a single dose or in divided doses every 12 hours...
Ceftriaxone is highly bound to human serum protein, probably albumin, the extent of binding decreasing from 96% to 83% over the concentration range 0.5 to 300 mg/L. This concentration-dependent serum protein binding is responsible for the non-linear dose-dependent pharmacokinetics of the drug. Th...
a Susceptibility interpretive criteria for Enterobacteriaceae are based on a dose of 1 gram IV q 24h. For isolates with intermediate susceptibility, use a dose of 2 grams IV q 24h in patients with normal renal function. b For Haemophilus influenzae, susceptibility interpretive criteria are based ...
Ceftriaxone preferentially localises in bile and mean concentrations of ≈153 and ≈44 mg/L are obtained 1 and ≈3 hours, respectively, after intravenous administration of lg dose. The drug is primarily eliminated unchanged by the kidneys; 45 to 60% of a 0.5 to 3g dose is excreted in the ...
11 The volume of distribution of an intravenous or intramuscular dose in septic patients is 6.48 to 35.2 L.4 Ceftriaxone has good enough CSF penetration to be used as an effective treatment of bacterial meningitis.5 Protein binding Ceftriaxone is 95% protein bound.11 Metabolism Metabolism of ...
Ceftriaxone, developed by Hoffmann-La Roche and patented in 1978, was approved by FDA in 1984 and marketed under the brand name Rocephin as a third-generation cephalosporin antibiotic to treat bacterial infections, exemplified by endocarditis, pneumonia, middle ear infections, skin infections, and uri...
The total daily dose should not exceed 4 g.Uses: For the treatment of the following infections when due to susceptible organisms:Bacterial septicemia due to Staphylococcus aureus, S pneumoniae, Escherichia coli, Haemophilus influenzae, or Klebsiella pneumoniae Bone and joint infections due to S aureus...
countries; major adjustments are not required until the estimated Creatinine clearance is 90% with 3- to 7-day Ciprofloxacin regimens (500 mg/day; >90% of patients were female), and were slightly lower with single-dose regimens. A3... R Davis,A Markham,JA Balfour - 《Drugs》 被引量: ...
Shadows which have been mistaken for gall stones have been detected by sonograms of the gallbladder, usually following higher than the standard recommended dose. These shadows are, however, precipitates of calcium ceftriaxone which disappear on completion or discontinuation of ceftriaxone therapy....