which are responsible for the discontinuation of Cefepime therapy. The symptomatic adverse reactions produced by Cefepime are more or less tolerable and if they become severe, they can be treated symptomatically, these include Vomiting, Abdominal cramps, Renal failure, Oral candidiasis....
Our case illustrates that cefepime toxicity may still occur in patients who are dose-adjusted for renal insufficiency. It also underscores the importance of assessing for additional risk factors like history of stroke and seizures. Because cefepime-induced status epilepticus is completely reversible, ...
Renal excretion Pregnancy Category B Safe inLactation Adult (or child weight >40 kg) Low Dose (e.g. Mild to moderate severityUrinary Tract Infections) Dose: 0.5 to 1 g IM/IV every 12 hours Moderate Dose (e.g.Pneumonia) Dose: 1 to 2 g IV every 12 hours ...
(ii) Renal Impairment:Dose adjustment is required in renal impairment (creatinine clearance less than or equal to 60 mL/min). Cockcroft-Gault Equation can be used to calculate creatinine clearance.[11]Either the daily dose is reduced, or the dose is given at extended intervals for these patien...
Protein binding is relatively low (20%), and elimination is mainly renal. About 85% of the dose is excreted unchanged in the urine, with an elimination half-life of 2–2.3 h. The pharmacokinetics of cefepime is altered under certain pathophysiological conditions, resulting in high inter-...
Text Size Cefepime Injection (sef' e pim) Brand Name(s): Maxipime® IMPORTANT WARNING: [Posted 6/26/2012]ISSUE:There have been cases of a specific type of seizure called nonconvulsive status epilepticus associated with the use of cefepime (Maxipime), primarily in patients with renal impairmen...
mg/l. On the other hand, four patients clustered above this limit at the first dose, and two patients with altered renal function remained above this value at steady state, in spite of increasing the intervals of drug administration to 24 h and 36 h, respectively (right panel of Figure1)...
High dose cefepime therapy can indu... J Chandrasekhar,S Keller,PD Scanlon 被引量: 11发表: 2002年 Cefepime-induced encephalopathy with normal renal function Cefepime is a fourth-generation cephalosporin that is frequently used in a wide array of infections. Since approval for use, concerns have ...
To compare the safety of cefepime vs piperacillin-tazobactam in adults presenting to the hospital with suspected infection, we conducted the Antibiotic Choice on Renal Outcomes (ACORN) randomized clinical trial. Methods Trial Design and Oversight Between November 10, 2021, and October 7, 2022, we...
OBJECTIVE: To describe a case of cefepime neurotoxicity associated with acute renal failure that resulted in nonconvulsive status epilepticus. CASE SUMMARY... S Abanades,J Nolla,A Rodríguez-Campello,... - 《Annals of Pharmacotherapy》 被引量: 71发表: 2004年 ...