As described herein, the discovery that CEACAM1 is a direct ligand of TIM3 and has been shown in and in In addition, as demonstrated herein, CEACAM1 and TIM3 are co-regulated during the course of T-cell activation.BLUMBERG Richard S....
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1; CD66a); hepatitis A virus cellular receptor 2 (HAVCR2; TIM3)Cell culture and mouse studies suggest co-blockade of CEACAM1 and TIM3 could help enhance antitumor immunity to treat colorectal cancer.Science-Business eXchange...