Titanium dioxide (TiO2) has been shown to be a very effective PDT agent; however, the hypoxic tumour microenvironment partly affects its in vivo PDT efficacy. A peroxidase-like enzyme, Fe3O4, catalyses the decomposition of H2O2 in the cytoplasm to produce O2, helping overcome tumour hypoxia ...
Meanwhile, the porphyrin-like metalcenter in the FeNC@PAA nanoparticles could be used as a photosensitizerfor photodynamic therapy (PDT) of tumors, which could be enhancedby O2 generated in CDT. Furthermore, the FeNC@PAA nanoparticleswere also found to be effective in photothermal therapy (PTT) ...