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CAS: MF: MW:0 EINECS: Mol File:Mol File Browse by provinceCDK4 (D9G3E) Rabbit mAbSuppliersGlobal suppliers Beijing(1)Zhejiang(1)Member(6)All(6) Shanghai(3)Anhui(1) Recommend You Select Member Companies Company Name:Shanghai Aolu Biological Technology Co., Ltd.RecommendComplaint ...
The EZH2 (D2C9) Rabbit mAb (#5246), SUZ12 (D39F6) XP® Rabbit mAb (#3737), PARP (46D11) Rabbit mAb (#9532), Ubiquitin (P4D1) Mouse mAb (#3936), CDK4 (D9G3E) Rabbit mAb (#12790), Phospho-Rb (Ser807/811) (D20B12) Rabbit mAb (#8516), Tri-Methyl-Histone H3 (Lys27...
Palbociclib did not trigger apoptosis (Supplementary Fig. 3a–d), but significantly increased senescence-associated -galactosidase (SA- gal) activity and cellular complexity in a dose-dependent manner, both characteristics of cells undergoing senescence (Fig. 1d and Supplementary Fig. 3e,f). ...
3.其中,cdk4/6即细胞周期依赖性激酶4(cdk4)或细胞周期依赖性激酶6(cdk6),通过与细胞周期蛋白d结合,调节细胞周期从g1期转换到s期。cdk4与cdk6蛋白结构与功能相似,有71%的同源氨基酸,均能与cyclin d结合形成异源二聚体,磷酸化人视网膜母细胞瘤蛋白(rb),然后rb释放磷酸化前与其紧密结合的转录因子e2f,e2f活化后...
3a–d), but significantly increased senescence-associated ß-galactosidase (SA-ß gal) activity and cellular complexity in a dose-dependent manner, both characteristics of cells undergoing senescence (Fig. 1d and Supplementary Fig. 3e,f). Further, western blot analysis showed a dose-dependent ...
Cell-cycle entry relies on an orderly progression of signaling events. To start, cells first activate the kinase cyclin D-CDK4/6, which leads to eventual inactivation of the retinoblastoma protein Rb. Hours later, cells inactivate APC/CCDH1 and cross the