Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated. 仅用于科研。不用于...
CDK1 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 1G10 unconjugated Show Details recommended CDK1 antibody (AA 1-297) (ABIN560263) CDK1 Reactivity: Human WB, ELISA, IF, IHC (p) Host: Mouse Monoclonal 1A4-1A9 unconjugated Show Details CDK...
treatment with CDK1 inhibitors188,189,190. For instance, CDK1 inhibition can be a potential therapy for MYC-dependent breast cancer188. In the clinical application, the toxicities are manageable and clinical activity was observed when flavopiridol in combination with paclitaxel in patients with esophag...
The lack of understanding regarding the intrinsic signaling pathways involved in neuronal apoptotic death may be a critical factor, which contributes to translational therapy failures. An important network of death signals regulates ischemic neuronal death but most of them remain poorly understood. ...
To further study hTERT phosphorylation at T249, we generated a mouse monoclonal antibody that specifically recognize phosphothreonine 249 (TpMab-1). We confirmed that the antibody specifically detected phosphorylation signals of hTERT T249 phosphorylated by CDK1-cyclinB in vitro similar to anti-249T...
The technology can not only find differences in genetic and epigenetic phenotypes caused by tumours but also evaluate markers for disease diagnosis and therapy [8]. In this study, we analysed differentially expressed genes (DEGs) among RMS and ordinary striated muscle specimens retrieved from data...
Anti-integrin monoclonal antibody CNTO 95 enhances the therapeutic efficacy of fractionated radiation therapy in vivo. Mol Cancer Ther. 2008;7 (6):1569–1578. doi:10.1158/1535-7163.MCT-08-0288 3. Vizcaino C, Mansilla S, Portugal J. Sp1 transcription factor: a long-standing target in cancer ...
Walter, M.; Herr, P. Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy.Cells2022,11, 739. [Google Scholar] [CrossRef] Cortazar, A.R.; Torrano, V.; Martín-Martín, N.; Caro-Maldonado, A.; Camacho, L.; Hermanova, I.; Guruceaga, E.; Lorenzo-Martín, L.F.; Caloto...
activation are.2–7Although SAC is not required per se for killing,6 preventing SAC adaptation should improve the efficacy of AMCD by increasing mitosis duration.2–7 Therefore, further understanding of the mechanisms by which cells override SAC may help to improve the current AMCD therapy. Severa...
Moreover, the ability of shRNA-targeting DAP5 to sensitize human cancer cells treated with the anticancer drug taxol to apoptosis indicates that DAP5 has an excellent potential to serve as a target for anticancer therapy in the future. Experimental Procedures Cell Cultures, Synchronization Procedures...