The results show that concentrations of CDK1 inhibitor that only modestly impact the cell cycle can still markedly inhibit translation. These studies define a new role of CDK1 as a critical regulator of mTOR-independent translation and thus survival of FLT3-mutated AMLs. Further investigation of ...
www.nature.com/scientificreports OPEN received: 08 January 2015 accepted: 31 July 2015 Published: 02 September 2015 BA-j as a novel CDK1 inhibitor selectively induces apoptosis in cancer cells by regulating ROS Shixuan Zhang1, Yongming Bao2, Xiulan Ju3, Kangjian Li1, Haiyan ...
In addition, promising preliminary clinical activity has been observed in a Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors182. Furthermore, several clinical trials of CDK1 associated inhibitors combining with ...
The drug is a polo-like kinase inhibitor interfering with different molecular pathways that are essential for cancer cell growth. Rigosertib was developed by Onconova Therapeutics and is currently tested in several clinical trials for a number of other cancers including myelodysplastic syndrome (a ...
However, most of the medications targeting Wnt/β-catenin signaling remain experimental and therapeutically poor and did not achieve satisfactory efficacy, specificity, and safety in clinical trials.22 On the other hand, the use of dinaciclib, a small-molecule inhibitor of CDKs 1/2/5, showed ...
NCIC Clinical Trials Group [+1] NCT01627054/Completed临床2期IIT A Phase II Study of AT7519M, a CDK Inhibitor, in Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia The purpose of this study is to find out what effects a new drug AT7519M has on chronic lymphocytic leukemia...
[2]. DePinto W, et al. In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials. Mol Cancer Ther. 2006 Nov;5(11):2644-58. 存储条件 冰袋运输。粉末直接保存于-20℃,有效期2年。溶于DMSO。建议分装后-20℃避光保存...
We speculated that the stabilization of p27 would occur in the nucleus where this protein functions as a potent inhibitor of Cdk1, which is required both to promote cell cycle progression and block pro-apoptotic signals.15,16 Surprisingly, we found that PFKFB3 inhibition caused an increase in ...
(1234567890) Cell Biol Toxicol (2025) 41:16 metastasis, and chemoresistance of BRCA cells, aim- ing to uncover its mechanism of action and potential clinical applications. Vincristine is a broad-spectrum anticancer micro- tubule inhibitor that binds to tubulin, disrupting spindle formation and ...
RO-3306 is a selective, ATP-competitive, and cell-permeable CDK1 inhibitor that shows potent anti-tumor activity in multiple pre-clinical models. In this study, we investigated the effect of CDK1 expression on the prognosis of patients with ovarian cancer and the anti-tumorigenic effect of RO...