Cyclin-dependent kinases (CDK) form a conserved superfamily of eukaryotic serine-threonine protein kinases, which require binding to a cyclin protein for activity. CDK are involved in different aspects of cell biology and notably in cell cycle regulation. The comparison of nearly 50 plant CDK-...
cyclins1. Based on sequence similarity, plant CDKs can be subdivided into five classes: CDKs A, B, C, D and E2. CDK A is the most numerous class. This class comprises CDKs that are most closely related to the
SummaryCyclin-dependent kinases (CDKs) play key regulatory roles in diverse cellular functions, including cell-cycle progression, transcription and translation. In plants, CDKs have been classified into several groups, named A through to G, but the functions of most are poorly characterized. CDKCs...
P21 is a universal inhibitor of cyclin kinases. Investigates the significance of the deregulation of cell proliferation by molecular cloning of p21 protein and in vitro reconstruction of the quanternary ... Yue,Xiong,Hannon,... - 《Nature》 被引量: 6702发表: 1993年 E2F: a link between the ...
Background and Aims The cell cycle is controlled by cyclin-dependent kinases (CDKs), and CDK inhibitors are major regulators of their activities. The ICK/KRP family of CDK inhibitors has been reported in several plants, with seven members in arabidopsis; however, the phylogenetic relationship amon...
Functional requirements of protein kinases and phosphatases in the development of the Drosophila melanogaster wing Protein kinases and phosphatases constitute a large family of conserved enzymes that control a variety of biological processes by regulating the phosphorylation state of target proteins. They pla...
It has been proposed that the meiosis-specific protein kinase Ime2 functionally replaces the G1 cyclin–CDK complexes to promote Sic1 destruction. To investigate this possibility, we compared Cln2–Cdk1 and Ime2 protein kinase activities in vitro. Both enzyme preparations were capable of ...
Alternatively, extensive CTD phosphorylation may occur in only a subset of eukaryotes and, when present, this interaction results in greater stabilizing selection on both CTD and CDK sequences. Overall, our results suggest that transcription-related kinases originated after cell-cycle related CDKs, ...
PCNA complexes during early germination contain (any of) two PSTAIRE-containing protein kinases of 32 and 36 kDa that readily phosphorylate both histone H1 and maize retinoblastoma-related (RBR) proteins. Kinase activity in PCNA complexes is markedly inhibited by roscovitine and olomoucine, two ...
related protein (ZmRBR) (Sánchezet al., 2002). Moreover, PCNA-associated kinase activity is higher during the early hours of germination (0–6 h) than later (15–24 h) when the S phase begins, suggesting that it is a G1phase kinase. Interestingly, inin vitroassays, the fission ...