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[1] Megan L. Insco et al. ,Oncogenic CDK13 mutations impede nuclear RNA surveillance.Science380,eabn7625(2023).DOI:10.1126/science.abn7625 [2] How mutant protein leads to melanoma,Retrieved May 26, 2023, from https://news.harvard.edu/gazette/story/2023/04/researchers-discover-how-mutant-pr...
The regulatory subunit, cyclin remain dissociated under normal circumstances, complexation of cyclin with the catalytic subunit of CDK leads to its activation for phosphorylation of protein substrates. The primary role of CDKs is in the regulation of the cell cycle. Retinoblastoma protein (Rb) is ...
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While capitalizing on the leads you already have is key, the majority of dealers will still want fresh leads coming in. However, the true cost of the sales you get from lead providers must be examined. Focus on CRM reports that break down cost-per-lead and cost-per-sale per lead provide...
leads to cell cycle arrest in G1phase. Unlike p27Kip1, p21Cip1is present at high levels in cycling cells, keeping CDK activities under tight control. p21Cip1levels are induced in response to DNA damage and genotoxic stress as a result of activation of p53. Similar to p21Cip1and p27Kip...
Silencing MYC in multiple tumor models leads to tumor regression associated with remodeling of the tumor microenvironment28,29. Although multiple efforts have been made, it is still a big challenge to target MYC with clinical-grade small molecules, especially at the protein level34,35. In the ...
CycK complexes play a crucial role in embryo development, as genetic inactivation ofCycKin mice leads to a lethal phenotype at the stage of the morula-blastocyst transition [5]. However, currently we can only speculate about the specific function of the CycK complexes in embryo development. It ...