20192. Wenyi Luo, Faysal Fedda, Patrick Lynch, et al. CDH1 Gene and Hereditary Diffuse Gastric Cancer Syndrome: Molecular and Histological Alterations and Implications for Diagnosis and Treatment. Front Pharmacol.
3. Rachel S van der Post, Ingrid P Vogelaar, Fátima Carneiro, et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet. 2015; 52(6):361-74. 4. Munitiz Ruiz V, Jimeno P, Ruiz de Angulo D, et al. Is pro...
3. Rachel S van der Post, Ingrid P Vogelaar, Fátima Carneiro, et al. Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers. J Med Genet. 2015; 52(6):361-74. 4. Munitiz Ruiz V, Jimeno P, Ruiz de Angulo D, et al. Is pro...
CDH1 mutation carriers, who elect not to undergo prophylactic gastrectomy, should be offered screening every 6–12 months by upper endoscopy with multiple random biopsies. Women with CDH1 mutations are at increased risk for breast cancer and should be followed using high-risk guidelines as outlined ...
CDH1 mutation is the most frequent genetic alteration in hereditary diffuse gastric cancer (GC) and early onset diffuse GC patients. However, the incidence of CDH1 mutations in sporadic GC with or without family history has not been studied. This retrospective study includes a total of 993 Korean...
Identified transcript variants arise from mutation at consensus splice sites. Also, E-Cadherin has a potent invasive suppressor role and it is a ligand for integrin alpha-E/beta-7.相关搜索:重组人E钙粘蛋白(上皮型钙黏附素)(E-Cadherin)(CDH1),Recombinant Human Cadherin-1/E-Cadherin/CDH1...
ecad (redirected fromCDH1) Medical Encyclopedia Related to CDH1:Cadherin 1 ecad (ˈiːkæd) n (Biology) an organism whose form has been affected by its environment [C20: from ec(ology) + -ad1] Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins ...
【Key words】 Familial cancer syndrome;CDH1 gene;Germline mutation, Gastric cancer/Breast cancer 临床研究发现, 部分肿瘤发病有家族史, 即同一家系中肿瘤发病率很高 ,且发病年龄较轻。肿瘤的发生部位可以不局限于同一组织或器官 。此种家族发病有呈常染色体显性遗传特点, 以往称之为“癌家族” ,最近文献将其称...
screening strategies and therapeutic interventions for individuals at risk for HDGC; incidence of diffuse gastric cancer and other epithelial neoplasms in CDH1 mutation carriers; novel CDH1 mutations and molecular mechanisms for CDH1 inactivation which may predispose to diffuse gastric cancer susceptibility....
其中70%左右为致病型突变,包括截短突变(truncatedmutation)、剪接突变(splicingmutation)、无义突变(nonsensemutation);30%左右为错义突变(missensemutation),其临床意义还有争议。cdh1基因突变率在不同地区、种族的遗传性弥漫型胃癌检出差别很大,提示不同地区胃癌的发病机制可能不同。符合遗传性胃癌诊断标准的家系中,cdh1...