尼妥珠单抗是一种新的人源化anti-EGFR单抗,是中国NCCN建议的局部晚期鼻咽癌(LA-NPC)与放疗同步的药物治疗选择之一。但是目前尚未对尼妥珠单抗/RT和CDDP/RT的疗效进行比较,后者常导致严重急性毒性。 一项Ⅲ期随机临床试验,Ⅲ至ⅣB期NPC患者随机分组,在接受多西他赛 / CDDP / 5-氟尿嘧啶(TPF)诱导化疗(ICT)后,接...
In fact, CDDP given concurrently with RT leads to a potentiation of cell killing, based on an inhibition of the recovery of the radiation-induced damage and which is more evident in inherently sensitive cells to CDDP alone [1]. Furthermore, the simultaneous administration of RT and chemotherapy...
Continuous Infusion (CI) of cisplatin (CDDP) and concurrent radiotherapy (RT) in non resectable stage III lung cancerdoi:10.1016/0169-5002(91)91964-DRavasi, GBedini, AvMilani, FGramaglia, ATavecchio, LSpreafico, CMarchiano, ALung Cancer...
摘要: P-62 A dose finding study of 254S-iv & CDDP-ia+TAE for advanced uterine cervical cancer 脇本 栄子 , 安達 進 , 小笠原 利忠 , 山田 幸生 , 柴原 浩章 , 竹村 正 , 香山 浩二 , 山崎 則行 Acta Obstetrica et Gynaecologica Japonica 51(Supplement), "S-390", 1999-02-20...
(RT-PCR) and immunocytochemistry analysis.Immunohistochemical analysis was performed to compare the levels of HIF-1α,MRP1 and LRP in transplanted tumors among different groups.In orderto calculate the cisplatin resistant,MTT assay was performed to detect the cell half-maximum inhibitory concentration ...
According to a recent report, JMJD2A can promote CDDP resistance in ovarian cancer cells [16]. Here, we aimed to examine the effect of JMJD2C on the drug resistance of uveal melanoma cells. RT-qPCR results displayed that the expression of JMJD2C in uveal melanoma tissues was significantly...
Bruno Chauffert10, Pierre Michel11, Jean-Louis Legoux12, Philippe Rougier4, Laurent Bedenne2, Jean-François Seitz1,13, for the Fédération Francophone de Cancérologie Digestive 1Assistance Publique-Hôpitaux de Marseille, Hôpital Timone, Université de la Méditerranée, Marseille, Fr...
Radiation (RT) were performed in 17 patients (CRT group), and not in the other 16 patients (CT group).Results: For all patients, response rate was 63.6% (no complete response and 21 partial response). Response rate of the CRT group was 76.5%, which was rather higher than that of the...
结论:①RAE对Ec9706/cDDP细胞存在细胞毒性作用,与RAE浓度有关.②DDP单独作用,DDP对Ec9706/cDDP的IC50为 43.59 μ g/ml,,DDP与非细胞毒性剂10 μ g/mL的RAE共同作用,DDP对Ec9706/cDDP的IC50降低26.27 μ g/mL,其逆转倍数为1 66.表明RAE可咀部分逆转Ec9706/cDDP对顺铂的耐药.@RT—PCR法分别检测两组细胞...
摘要: 目的探讨survivin与人大细胞多药耐药株H460/cDDP获得性耐药的关系.方法采用RT-PCR,Western blotting法检测耐药株H460/cDDP与敏感株H460的survivin表达:用靶向 survivin siRNA经脂质体介导转染入耐药株H460/cDDP,抑制survivin表达:用MTT法分别检测Taxol,DDP 对耐药株H460/cDDP的细胞毒作用....