In fact, CDDP given concurrently with RT leads to a potentiation of cell killing, based on an inhibition of the recovery of the radiation-induced damage and which is more evident in inherently sensitive cells to CDDP alone [1]. Furthermore, the simultaneous administration of RT and chemotherapy...
Continuous Infusion (CI) of cisplatin (CDDP) and concurrent radiotherapy (RT) in non resectable stage III lung cancerdoi:10.1016/0169-5002(91)91964-DRavasi, GBedini, AvMilani, FGramaglia, ATavecchio, LSpreafico, CMarchiano, ALung Cancer...
方法:对前期实验建立的耐顺铂(cisplatin,CDDP)细胞株OSC-19/CDDP,采用CCK-8法检测其对不同化疗药物的耐药性;RT-PCR检测亲代与耐药株的多药耐药基因1(multidrugresistance1,MDR1)表达。通过微阵列芯片筛查在OSC-19/CDDP与亲本细胞OSC-19中差异性表达的miRNAs,并通过RT-PCR进一步验证基因芯片的结果。结果:人舌癌多药...
MHCIb,HLA-DR) ofSKo” /CDDP cel l streated wi thor wi thout CI K cel l s were detected by el ectronmi croscope,^斤rTand FCM.Thechangesof cyto喇ne(IL-2,TNF· d,IFN-T,GM—CSF) i nesra of SCID mi cebeari ngSK-oV3/CDDP cel l sweredetectedbyradi oi mmuni tandELl SA....
39.肺癌に対するCDDP(C)+VNR(V)併用放射線療法(RT)のpilot study(第72回日本肺癌学会関西支部会) 遠藤,正浩,高田,佳木,大林,加代子,... - 《Japanese Journal of Lung Cancer》 被引量: 0发表: 2000年 42. 非小細胞肺癌に対する術前CDDP+VNR同時併用放射線療法施行症例の治療成績(第76回 日本肺癌...
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多药耐药口腔腺样囊性癌细胞株(Acc-3／CDDP)的建立及其细胞中相关耐药基因表达的变化
药细胞系;用MTr法检测Ace一3/CDDP细胞的耐药指数,RT-PCR检测多药耐药基因MDR一1、MRP一1、GST一1T和Bel一2基因的 mRNA表达水平。结果:Acc一3/CDDP对CDDP、5一氟尿嘧啶(5～Fu)、长春新碱(VCR)、氨甲喋呤(MTX)和平阳霉素(PYM)的耐 药指数(Resistancefactor,RF)分别为8. ...
表明一定浓度的 RAE 对人胃癌 SGC7901 细胞对顺铂的耐药可以起到部分逆转的作用.③RT-PCR法分别检测两组细胞 polβ的表达,对照组显示 polβ基因的表达明显增高,说明一定剂量的 RAE 能够降低 SGC7901/cDDPpolβ的基因表达水平,这一研究为藤梨根提取物抗肿瘤作用及其逆转耐药提供了实验方向,为进一步临床应用以及...