Chemoprevention represents a promising strategy to reducing the incidence of prostate cancer which afflicts more than 240,000 males annually in the U.S. 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its C-28 methyl ester(CCDO-Me) and C-28 imidazole (CDDO-Im) ...
These results indicate that by enhancing autophagy, CDDO-Im-mediated activation of Nrf2/HO-1 signaling could be a novel therapeutic strategy to minimize the adverse effects of hepatic I/R injury. Cell Death and Disease (2017) 8, e2983; doi:10.1038/cddis.2017.386; published online 10 August ...
Finally, given the fact that we have previously shown that 1) 15d-PGJ2 and TZDs repress NF-κB activation in lymphoid cells [19] and 2) NF-κB modulators, either alone or in combination with other anticancer agents, is a therapeutic strategy undergoing intense preclinical and clinical studies...
Emerging evidence suggests that inhibiting LonP1 or other quality control proteins in mitochondria (54, 55) and endoplasmic reticulum (56) of cancer cells or immunosuppressor cells (57) is a potential strategy for disabling oncogenic progression. The endoplasmic reticulum (ER) and mitochondrial ...
As part of developing a national strategy we are also looking at the benefits of running a multi-PID consortium. Although this work is focussed on UK research it is relevant for a data-driven government that wants to encourage the discoverability and use of its outputs – publications and ...
To be more specific, we suggest a new hybridization strategy that integrates CDDO’s local search capabilities with traditional HS’s worldwide exploration potential. The solution space can be efficiently searched with this method, resulting in faster convergence and better solutions overall. The ...
分业务看,快递业务实现收入206.09亿元,同比下降4.65%,物料销售和其他业务分别实现收入0.21/9.43亿元,同比下降40.70%/21.40%。今年公司快递业务实现收入占比95.53%,与去年同期相比占比有所提高,扣非后净利润7.89亿元,同比增长47.97%,维持公司增持评级。 支撑评级的要点...
These results indicate that by enhancing autophagy, CDDO-Im-mediated activation of Nrf2/HO-1 signaling could be a novel therapeutic strategy to minimize the adverse effects of hepatic I/R injury.doi:10.1038/cddis.2017.386Xu, DongweiChen, Lili...
According to the present invention, a dual-prodrug strategy is used, specifically, CUK of a CDDO drug is subjected to prodrug protection with a leucine acyl group of an LAP response fragment, and is coupled to an active fragment of tetramethylpyrazine alcohol to form a CDDO/tetramethylpyrazine ...