Presumably a signal (perhaps delivered by Lck, ERK, or Notch1?) is then delivered that results in the downregulation of CD4 synthesis and the production of more CD8+ cells than CD4+ cells bearing this Vα sequence. A mechanism such as this could account for the AV8/CD8 bias that is ...
Cloning and sequence analysis of goCD8α cDNA The full-length cDNA of goCD8α [GenBank: KC476104] is 1459 bp in length and contains a 29 bp 5′-untranslated region (UTR), a 711 bp single ORF, and a 719 bp 3′-UTR (Fig. 1). A eukaryotic polyadenylation signal (AATAAA) was found...