ifn γ介导的CD274 (PD-L1)和Lgals9(半乳糖素-9 (Gal-9))的诱导在衰老细胞中是未治疗细胞5- 10倍(Fig. 3h)。 将乳腺肿瘤移植到Ifng−/−小鼠中进一步证实CD274和Lgals9的最大诱导表达需要阿霉素治疗和来自宿主的IFNγ的二者联合(Fig...
最后,作者使用肿瘤模型和EAE自身免疫病模型验证cis-CD80/PD-L1顺式作用的生理功能。肿瘤模型中,Cd274Y56A、Cd80L107E基因突变小鼠缺乏cis-CD80/PD-L1,不能有效抑制PD-1作用,对蛋白疫苗和BM-DC诱导的抗肿瘤免疫不响应,且伴随着CD8 T细...
目前免疫学家们分离出了很多种不同的共刺激分子,其中研究最清楚的一种是表达在抗原呈递细胞(APC)表面的B7家族蛋白,目前B7家族包括11个成员,大多是明星分子,例如B7-1(CD80),B7-2(CD86),B7-H1(PD-L1,CD274),B7-DC(PDCD1LG2,PD-L2,CD273),B7-H2(B7RP1,ICOS-L,CD275),B7-H3(CD276),B7-H4(B7x,B7S...
The B7 family of cellsurfacemolecules, a subset of Ig-SF molecules, include molecules structurally related to the originally defined co-stimulatory moleculesCD80(B7-1) and CD86(B7-2) [97]. DC also express CD273 (PD-L2) and CD274 (PD-L1), which are ligands for the checkpoint inhibitor PD...
CD274CD274 CD200R1CD200R1 NECTIN2NECTIN2 BCAMBCAM KIRREL3KIRREL3 NECTIN4NECTIN4 CADM1CADM1 KIRREL2KIRREL2 AGERAGER VCAM1VCAM1 官方名通用名试剂列表 MCAMMCAM CD2CD2 SIGLEC12SIGLEC12 CD276CD276 CRTAMCRTAM MAGMAG NECTIN1NECTIN1 BTN3A1BTN3A1 ...
The first population was characterized by interferon response genes, typified by Cd274 , whose expression required chemotherapy to enhance chromatin accessibility, enabling recruitment of IRF1 transcription factor. A second population was characterized by p53 signaling, typified by CD80 expression. Treating ...
(FM23), interferon γ (IFN-γ; 14-4-4s) and Fc Block (2.4G2), PD-L1 (BV711 [Rat anti-mouse CD274, clone MIH5], matched BV711-conjugated isotype control [mAb; rat IgG 2a]), and PD-1 (BV421 [Hamster anti-mouse CD279, clone J43]) were purchased from BD Biosciences (San ...
[0092] 如本文所用,术语“程序性死亡配体1(PD‑L1)”称为CD274或B7‑H1,并且是存在于 癌细胞表面或造血细胞上的蛋白质。存在于癌表面的PD‑L1可结合存在于T细胞表面的PD‑ 1。PD‑L1抑制剂可以是例如阿特珠单抗、阿维鲁单抗 德瓦鲁单抗 KN035、CK‑301、AUNP12、CA‑170和BMS‑986189。 [...
Targeted blockade of the checkpoint molecule programmed cell death 1 (PD-1) can activate tumor-specific T cells to destroy tumors, whereas targeted potentiation of PD-1 is expected to suppress autoreactive T cells and alleviate autoimmune diseases. Howev
abx190027人程序性细胞死亡1配体1(CD274)CLIA试剂盒96 tests$855.5+ abx190028人凋亡调节因子Bcl-2(BCL2)CLIA试剂盒96 tests$855.5+ abx190029人凋亡诱导因子(AIF)CLIA试剂盒96 tests$855.5+ abx190030人Pim-1癌基因(PIM1)CLIA试剂盒96 tests$855.5+ ...