TNF-α and CD8+ T cells me- diate the beneficial effects of nitric oxide synthase-2 deficiency in pulmonary paracoccidioidomycosis. PLoS Negl Trop Dis 2013; 78: e2325.Bernardino S, Pina A, Felonato M, Costa TA, Frank de Araujo E, Feriotti C, ...
于是将众多克隆中能选择性靶向CD8β的抗体与非α IL-2变体融合(CD8β-IL2β*γ,下文简称为AB248),体外细胞培养结果显示该抗体表现出高度的稳定性,对人CD8+T细胞中的Ki67诱导作用比NK细胞强6000倍以上,且接受TCR刺激的CD8+T细胞在AB24...
in vivo CD8+ T cell depletion Uddin, M. N., et al. (2014). “TNF-alpha-dependent hematopoiesis following Bcl11b deletion in T cells restricts metastatic melanoma.” J Immunol 192(4): 1946-1953. in vivo CD8+ T cell depletion Walsh, K. B., et al. (2014). “Animal model of respir...
5 resident markers (RUNX3, NR4A1, CD69, CXCR6, and NR4A3), 7 cytotoxicity associated genes (PRF1, IFNG, GNLY, NKG7, GZMB, GZMA, CST7, and TNFSF10), 5 exhausted markers (CTLA4, HAVCR2, LAG3, PDCD1, and TIGIT) 6 costimulatory molecular genes (ICOS, CD226, TNFRSF14, TNFRSF25, ...
这种自然的肿瘤铁死亡机制在概念上类似于不同细胞因子(如 TGFβ和IL-6)组合诱导 Th17 细胞或 Th22 细胞【8-10】, 同样, 类似于TNFα 和 IFNγ组合诱导以炎症细胞死亡为特征的 PANoptosis【11】。这一在肿瘤免疫研究中得到的结果, 将...
7 cytotoxicity associated genes (PRF1, IFNG, GNLY, NKG7, GZMB, GZMA, CST7, and TNFSF10), 5 exhausted markers (CTLA4, HAVCR2, LAG3, PDCD1, and TIGIT) 6 costimulatory molecular genes (ICOS, CD226, TNFRSF14, TNFRSF25, TNFRSF9, and CD28) ...
抗原DR;ICOS,诱导性T细胞共刺激因子;IFN,干扰素;IL,白介素;KLRG,杀伤细胞凝集素样受体亚家族G;LAG,淋巴细胞活化基因;MIP,巨噬细胞炎症蛋白;PD-1,程序性细胞死亡蛋白1;RANTES,调节活化正常T细胞表达和分泌细胞因子;T-bet,T细胞表达的T-box;TIM、T细胞免疫球蛋白和黏蛋白结构域...
7 cytotoxicity associated genes (PRF1, IFNG, GNLY, NKG7, GZMB, GZMA, CST7, and TNFSF10), 5 exhausted markers (CTLA4, HAVCR2, LAG3, PDCD1, and TIGIT) 6 costimulatory molecular genes (ICOS, CD226, TNFRSF14, TNFRSF25, TNFRSF9, and CD28) ...
Multiple T cell effector molecules play a role in anti-microbial immunity mediated by memory CD8 T cells including IFN-gamma, perforin, TRAIL, FasL and TNF-alpha. However, it is not known which effector pathways are required for memory CD8 T cell-mediated immunity to liver stage Plasmodium ...
7 cytotoxicity associated genes (PRF1, IFNG, GNLY, NKG7, GZMB, GZMA, CST7, and TNFSF10), 5 exhausted markers (CTLA4, HAVCR2, LAG3, PDCD1, and TIGIT) 6 costimulatory molecular genes (ICOS, CD226, TNFRSF14, TNFRSF25, TNFRSF9, and CD28) ...