The importance of metabolic pathways in regulating immune responses is now well established, and a mapping of the bioenergetic metabolism of different immune cell types is under way. CD8 T cells and natural killer (NK) cells contribute to cancer immunosu
CD8+ T cells play a critical role in specific immunity. In recent years, cell therapy has been emerging rapidly. The specific cytotoxic capabilities of these cells enable them to precisely identify and kill cells presenting specific antigens. This has de
三阴性乳腺癌(TNBC)是雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER2)表达均为阴性的一类乳腺癌,临床上常规的治疗手段包括手术、放射治疗及化疗。肿瘤的免疫治疗是目前的研究热点之一,其中起重要作用的是肿瘤特异性分化群8(CD8)阳性T细胞。在基础研究方面,CD8阳性T细胞在TNBC的过继性免疫治疗和肿瘤疫苗...
The importance of metabolic pathways in regulating immune responses is now well established, and a mapping of the bioenergetic metabolism of different immune cell types is under way. CD8 T cells and natural killer (NK) cells contribute to cancer immunosu
Some third parties are outside of the European Economic Area, with varying standards of data protection. See our privacy policy for more information on the use of your personal data. Manage preferences for further information and to change your choices. Accept all cookies ...
*– for comparison with intact control, ●–for comparison with LLC, +– for comparison with naive T-cells (Mann–Whitney test, p-value < 0.05). All data were obtained using flow cytometry Full size image Therapy with naive CD8+ T-cells had a controversial effect on the lung of ...
Results: Following false discovery rate (FDR) correction, we identified three immune cell phenotypes as protective factors for AR: Naive CD8br %CD8br (odds ratio (OR): 0.978, 95% CI = 0.966-0.990, P = 4.5x10-4), CD3 on CD39+ activated Treg (OR: 0.947, 95% ...
Memory T cells exhibit superior responses to pathogens and tumors compared with their naive counterparts. Memory is typically generated via an immune respo... C Haluszczak,AD Akue,SE Hamilton,... - 《Journal of Experimental Medicine》 被引量: 372发表: 2009年 CD4+ T cells clear virus but au...
ObjectiveTo explore the effect of CD40 knock out on the cytotoxic function of CD8+ T cell of mice with cigarette smoke-induced emphysema. MethodsA total of 40 male C57 mice were divided into four groups according to the random number table, including CD40+ /+ control group, CD40+ /+ smoke...
84 T2/late treatment-naive patients with chronic active hepatitis C (aged 20–67 years; median 45 years); diagnosis was based on the finding of positive serum HCV-RNA and alanine aminotransferase (ALT) elevation for at least 1 year; 20 T2/late chronic active hepatitis C genotype 1 patients...