1+CD3+ T cells that expresses an invariant TCR has been named "NKT cells." Here, we describe NK marker expression on a broad spectrum of MHC class I- and MHC class II-restricted T cells that are induced after acute viral infection. From 5 to >500 days post lymphocytic choriomeningitis ...
CD1d-dependent NKT cells have been extensively studied; however, the function of CD8+NKT-like cells, which are CD1d-independent T cells with NK markers, remains unknown. Here, we report that CD1d-independent CD8+NKT-like cells, which express both T cell markers (TCRβ and CD3) and NK cell...
but the potential dysregulation of peripheral immunity has not been systematically investigated for idiopathic PD (iPD). Here we showed an elevated peripheral cytotoxic immune milieu, with more terminally-differentiated effector memory (TEMRA) CD8 T, CD8+NKT cells and circulating cytotoxic molecules ...
Liver-associated lymphocytes that express NK1.1 marker (NKT LAL) play a role in immune modulation. Aim: To determine the role of the liver and of NKT LAL in determining the CD4+/CD8+ balance during tolerance induction. Methods: Colitis was induced in C57 mice by intracolonic instillation of...
T cells were further classified into CD4 T cells, CD8 T cells, or NKT cells based on the expression of CD4, CD8A, or NCR3 (Figure 1D). NK cells were identified based on CD3D as a negative marker combined with the expression of NKG7, GNLY, GZMB, PRF1, and NCR3 as positive markers...
目前发现具有耐受调节作用的 T 细 胞包括 了 CD4 Treg 细胞 、 Th3 细胞 、 Tregl 细胞 、 NKT ( nature killer cells) 细胞、 Thl7 细胞和CD8 Treg细胞等⋯ 。CD4 Treg 是公认 的调节细胞 , 它特异 性的表达 Fo xp3,即 CD4 CD25 Fo xp3 Treg 细胞。2005 年 Biskirska 的研 究小组报道 了 CD8 ...
Unlike NK1.1−CTLs, CD8+NKT-like cells also exhibit the capability to kill myeloid-derived suppressor cells (MDSCs) in an antigen-specific manner, indicative of their potential role in clearing tumor antigen-bearing MDSCs to improve the antitumor microenvironment. In vitro blocking ...
Further studies on specific CD8+NKT cells function and their role in pregnancy beneficial effects on MS are warranted to move forward more effective MS treatments. 展开 关键词: pregnancy regulatory immune response postpartum NK cell CD3+CD56+CD8+cells multiple sclerosis ...
NKG2D is a lectin-like receptor protein that is expressed on NK, NKT, γδT, and some αβCD8+ T cells [16, 17]. NKG2D is detected on CD8+T cells in both humans and mice, in mice on active CD8+T cells only [18, 19]. As an activating receptor, NKG2D regulates innate and ...
(CD4+ Trm), regulatory T-cells (Treg), effector memory CD8+ T-cells (CD8+ Tem), tissue-resident memory CD8+ T-cells (CD8+ Trm), early exhausted CD8+ T-cells (early CD8+ Texh), terminal exhausted CD8+ T-cells (term CD8+ Texh), natural killer T-cells (NKT cell), and NK ...