cells effectively eliminates CD7+ AML cell lines, primary CD7+ AML, and colony-forming cells but spares myeloid and erythroid progenitor cells and their progeny. In a xenograft model, CD7 CAR T?cells protect mice against systemic leukemia, prolonging survival. Our results support the feasibility ...
（Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial）⭐5. WU-CART-007（Wugen 的CD7-CAR-T，Ⅱ期）—公开的IND效果好，预计主要副作用是T细胞再生障碍 目前只有IND数据。（1）策略：为了产生WU-CART-007细胞，使用CRISPR / Cas9...
他们新的简化方法选择了一种有利的T细胞类型,并在实验室中显示出对抗复发的T细胞急性淋巴细胞白血病(T-ALL)的前景。相关研究结果于2022年8月1日在线发表在Blood期刊上,论文标题为“Engineering Naturally Occurring CD7 Negative T Cells for the Immunotherapy of Hematological Malignancies”。 急性淋巴细胞白血病(ALL)...
4.CAR-T(北京博仁医院CD7-CAR-T,Ⅱ期)—Ⅰ期数据显示完全缓解的有效性,可控的安全性 (Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial) 5. WU-CART-007(Wugen 的CD7-CAR-T,Ⅱ期)—公开的IND效果好,预计主要副作用是T细胞再...
⭐4.CAR-T(北京博仁医院CD7-CAR-T,Ⅱ期)—Ⅰ期数据显示完全缓解的有效性,可控的安全性 (Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial) ⭐5. WU-CART-007(Wugen 的CD7-CAR-T,Ⅱ期)—公开的I...
T cells regenerating after lymphodepletion lacked CD7 expression, were polyclonal and responded to SARS-CoV-2 vaccination; CD7+ immune cells reemerged concomitantly with CAR T cell disappearance. In conclusion, autologous anti-CD7 PEBL-CAR T cells have powerful antileukemic activity and are potentially...
(Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial) ⭐5. WU-CART-007(Wugen 的CD7-CAR-T,Ⅱ期)—公开的IND效果好,预计主要副作用是T细胞再生障碍 目前只有IND数据。
The ratio of CD19 CAR-T cells in patient PBLC samples showed a significant increase on Day 7 following infusion, and the CAR-T cell peak appeared on Day 10 with a peak of 14.71% (range: 0.11%-89.33%), and then quickly decreased to 0.23% (range: 0%-82.88%) on Day 21 (Figure 1...
Clonal expansion of CD4+ T cells is a characteristic finding in patients with RA and is only infrequently found in patients with psoriatic arthritis and healthy controls. Expanded CD4+ clonotypes are present in the blood, infiltrate into the joint, and persist over years. We have not addressed...
参考文献:Eradication of T-ALL cells by CD7 targeted universal CAR-T cells and initial test of ruxolitinib-based CRS management,doi:10.1158/1078-0432.CCR-20-1271; 识别微信二维码,添加生物制品圈小编,符合条件者即可加入生物制品微信群! 请注明:姓名+研究方向!