Human intrahepatic CD69+CD8+T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity. Sci. Rep. 7, 6172 (2017).Stelma F, de Niet A, Sinnige MJ, et al. Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced...
CTL介导的细胞免疫反应.CTLs是一群CD8 + 的T细胞,从前体细胞毒T细胞(Tcp)活化、增殖 分化而来,这个过程中 ! -干扰素(IFN- ! )起了相当重要的作用 [1,2] .然而由于方法的限制,对 于CD8 + T细胞亚群表达细胞因子的情况未完全清楚.近年来发展成熟的利用流式细胞术在 单细胞水平检测各亚群细胞内细胞因子表达的...
CD8T淋巴细胞早期激活标志CD69的表达.方法:静脉采集慢性乙肝患者普通肝素抗凝血2ml,在植物血凝素(PHA)20g/ml条件下进行全血培养,4h后用双色免疫荧光标记流式细胞术检测CD4,CD8T淋巴细胞CD69的表达.结果:正常人外周血只有很少量CD4与CD8T淋巴细胞表达CD69分子,经PHA刺激后CD4与CD8T淋巴细胞CD69的表达率明显升高,...
表达 CD69 的活化 T细胞主要是 CD8+CD45RO+,而且主要受 IL-15 诱导以及与表达 ICAM-1 的活化内皮接触有关。当外源性刺激消失后,活化 T 细胞的 CD69 表达即可快速降低。因此,淋巴细胞暴露于某种抗原刺激后表达 CD69的程度可反映细胞对于该抗原的反应程度。
RESULTS: CD69 expression on CD3+, CD4+, and CD8+ T-cell subsets was low in controls and transplant recipients without allograft rejection. In contrast, patients with renal allograft rejection showed significantly elevated percentages of CD69+ cells in the CD3+ (P<0.01) and CD8+ subsets (P<...
glial cellsPD‐L1IntroductionPrevious work from our laboratory has demonstrated in vivo persistence of CD103+CD69+ brain resident memory CD8+ T‐cells (bTRM) following viral infection, and that the PD‐1: PD‐L1 pathway promotes development of these TRM cells within the brain. Although glial ...
Fig. 1. Localization and phenotype of CD8+ memory T cell following infection with a respiratory virus. During the acute infection, CD8+ T-cell memory is established in the lymphoid organs and the lungs. By 30 d post-infection, 21 d after viral clearance, substantial numbers of memory CD8+...
对于HLA‐DR的研究,必须在染色方案中包括T细胞标志物(因为CD4+和CD8+T细胞之间HLA‐DR的预后意义不同),APC的标志物可以用作排除APC用。对于CD38的研究,方案中必须纳入初始和记忆性T细胞亚群的标志物,这对于区分那些由于T细胞活化而表达CD...
In this study, we analyzed the role of CD69, an early leukocyte activation marker, in regulating effector T cell egress from peripheral tissues. We provide evidence that CD69 surface expression by skin-infiltrating CD8 T cells can be regulated at multiple levels, including local Ag stimulation ...
CD103(+)CD8(+) tissue-resident memory T cell infiltration predicts clinical outcome and adjuvant therapeutic benefit in muscle-invasive bladder cancer BACKGROUND: CD103(+)CD8(+) tissue-resident memory T (T-RM) cells, associated with better overall survival among various malignancies, are thought ...