Exosomes take part in cellular communication, excretion of proteins, immune response, and are also involved in development of some neurodegenerative diseases and cancer. The mechanism through which they get in and out of cells is not clear. To address this issue, we have generated a stable HeLa...
Interestingly, interaction between syntenin-1 and ALIX is critical for the production of exosomes, nanovesicles released by cells after MVEs fuse with the plasma membrane44. This, and other overlapping functions of CD63, syntenin-1 and ALIX such as viral egress from cells, ubiquitin-independent ...
Several studies have demonstrated that the contents of small EVs can shape the tumor microenvironment by modifying drug response or tumor angiogenesis (Li and Nabet, 2019; Todorova et al., 2017). Studies have shown that EVs, including exosomes, can carry angiogenic factors such as VEGF and ...
Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem., 273 (1998), pp. 20121-20127 View PDFView articleView in ScopusGoogle Scholar 48 H. Kita, M. Kato, G-J Gleich, R-T Abraham Tyrosine...
in EVs than CD63. Thus, in HeLa cells, ectosomes are more prominent than exosomes. By comparative proteomic analysis and differential response to neutralization of endosomal pH, we identify a few surface proteins likely specific of either exosomes (LAMP1) or ectosomes (BSG, SLC3A2). Our work...
Exosomes are commonly known to play a role in the removal of unwanted proteins from cells(Bellingham et al., 2012). In fact, exosomes also have a role in various pathways and contribute to the intercellular communication, immune response and the pathogenesis of many diseases including ...
Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem., 273 (1998), pp. 20121-20127 View PDFView articleView in ScopusGoogle Scholar 48 H. Kita, M. Kato, G-J Gleich, R-T Abraham Tyrosine...