CD2-CD58 信号轴对免疫突触的形成至关重要,能够调节免疫细胞的增殖、活化和粘附,并分别触发免疫细胞和靶细胞的信号传导1。最近的研究表明该轴具有增强抗肿瘤免疫的潜力,成为有潜力的治疗靶点。CD2-CD58相互作用参与调节自身免疫性疾病、肿瘤的免疫逃避、抗病毒反应和免疫排斥反应,目前正在开发针对CD2和CD58的靶向疗法...
CD58-CD2轴的缺陷通过T细胞活化减少、肿瘤内T细胞浸润和增殖受损以及同时增加PD-L1蛋白稳定性来促进免疫逃逸。mIHC结果显示CD58 敲除(KO)肿瘤的CD8+ TILs浸润比野生型(WT)肿瘤低100倍。随后,通过实验证明CMTM6对CD58的稳定性和CD58缺失时PD-L1的上调至关重要,进一步证明CMTM6是癌细胞共刺激和共抑制信号的阴阳关键...
Gollob JA,Ritz J.CD2-CD58 interaction and the control of T cell interleukin-12 responsiveness.Adhesion molecules link innate and acquired immunity. Annals of the New York Academy of Sciences . 1996Gollob JA,Ritz J. CD2-CD58 interaction and the control ...
Patricia Ho2022The CD58:CD2 axis is co-regulated with PD-L1 via CMTM6 and governs anti-tumor immunity, 视频播放量 562、弹幕量 3、点赞数 37、投硬币枚数 23、收藏人数 19、转发人数 1, 视频作者 Johnson_Han, 作者简介 致力于抗肿瘤免疫领域的知识分享,相关视频:
This research spotlight featured the immune function of CD2-CD58 axis and discussed the research applications and drug development targeting this axis.
(b) Topology of the binding domains of CD2 and CD58. (c) Representation of the adhesive complex involving domains D1. This corresponds to the entry 1QA9 (Wang et al., 1999), with most of the charge amino acids in the binding interface in bond representation. All of the charged ...
<正>CD58 and CD2 have been known as a pair of reciprocal adhesion molecules involved in the immune modulations of CD8~+ T and NK-mediated cellular immunity in humans and several other mammals. However, the functional roles of CD58 and CD2 in CD4~+ T-mediated adaptive humoral immunity收藏...
itisverysensitivetothedissociationequilibrium constant and the concentrations of CD2 and CD58.Keywords—Kinetics,Diffusion,Lymphocyte,Movingboundary,Equilibrium constant, Receptor–ligand bonds.NOMENCLATUREα rate of increase in the contact area(µm 2 /molecule)ε 1−12 , dimensionless parameters defined...
CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells. J. Immunol. 195 (2), 477-487... J Leitner,D Herndler-Brandstetter,GJ Zlabinger,... - 《Journal of Immunology》 被引量: 23发表: 2015年 CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28(-)CD8(+)...