特别是,TEMRA 群体(定义为 T 细胞分化的终末阶段)表达 CD57 但不表达 PD1,而效应记忆样细胞(CD28-CD45RA-)通常高表达PD1但却无CD57。箭头表示在分化过程中 PD1 和 CD57 可能丢失/获得的途径(目前尚无共识)。 信源:Larbi A, Fulop T. From "truly naïve" to...
•理解免疫衰老•开发免疫治疗•监测疾病进展•预测治疗反应 综述指出,这些T细胞亚群可能作为疾病进展和治疗反应的生物标志物,特别是在慢性免疫活化相关的疾病中。 参考文献:Strioga M, Pasukoniene V, Characiejus D. CD8+ CD28- and CD8+ C...
虽然有一项研究在静息淋巴细胞的IL-6受体gp130上鉴定了CD57表位,但尚未鉴定表达CD57/gp130的细胞,并且尚未报道关于T细胞或NK细胞上表达CD57的分子的全面分析。 CD57最初被视为自然杀伤细胞的特征,然而如今它更广泛地被用于标记T细胞的衰老化过程。在持续的免疫刺激下,记忆T细胞会从CD28+CD57-转变为CD28-CD57+,C...
NK type T cellsrisk factorstem cell sourceSummary To clarify the immune response of CD57 + T cells (most of them are CD8 + ) in peripheral blood (PB) against alloantigens in order to elucidate the T helper 1 (Th 1) immune response, we assessed the role of CD57 + T cells in IFN...
PSK may suppress CD57+ T cells to improve survival of advanced gastric cancer patients International Journal of Clinical OncologyJ. Akagi, H. Baba, PSK may suppress CD57(+) T cells to improve survival of advanced gastric cancer patients, ......
CD57+ and CD28- cells among both circulating CD4+ and CD8+ T lymphocytes of untreated hemato-oncological patients (n = 54) as compared to healthy donors (n = 55), with CD57 and CD28 expression on the patients' T cells being largely reciprocal. Marked expansion of CD57+ cells among circ...
Involvement of CD4+,CD57+ T cells in the disease activity of rheumatoid arthritisochronosisalkaptonuriaarthritisEvidence showing that the frequency of CD4+,CD57+ T cells among CD3+ cells of RA patients had a significant correlation not only with ESR but also with the physical status of the ...
(+) T cells represent activated cytotoxic T lymphocytes at a terminal stage of their differentiation with evidence of immunological senescence, which have usually lost their cytotoxic properties to become "regulatory" T cells. Patients with a CD8(+)/CD57(+) T cell lymphocytes expansion can ...
1 The presence of CD4+ T cells in the synovial lesions has supported the hypothesis that T-helper cells, possibly responsive to arthritogenic antigens, are important in inducing and sustaining the inflammatory process,2, 3, 4 but recent evidence also indicates that the involvement of T cells ...
Increased Frequency of CD4+CD57+ Senescent T Cells in Patients with Acute Heart Failure: Exploring New Pathogenic Mechanisms with Clinical RelevanceBackgroundPathologic roles of T cells in heart fai... JC Youn,MK Jung,IC Kim,... - 《Journal of Cardiac Failure》 被引量: 0发表: 2018年 Charac...