结果发现,与肿瘤组织匀浆共培养的细胞中NKG2D+NK细胞和NKG2D+CD56dimNK细胞亚群频率较其他两组显著降低(图5)。 为进一步明确导致上述降低的细胞因子,我们检测了HCC患者血清中的多种与NKG2D表达相关的细胞因子以及HLA分子。结果显示,相比...
NKG2DIL-17HbA1cT cells expressing CD56 (identified as CD3+CD56+) play a potential role in activation or regulation of other immune cells by secreting various cytokines. We hypothesized that these cells expressing the natural group 2, member D (NKG2D) could produce high levels of interleukin (...
The patients were followed-up till December 2019 and the number of CD56+ NKG2D+ NK cells in the cases was a significant predictor for postoperative fertility as determined by different COX regression models (crude HR = 0.220, 95% CI = 0.059–0.822; adjusted HR = 0.127, 95% CI = 0.024–...
a bigger fraction of the CD56brightNK cells expresses intracellular IFN-γ upon stimulation with IL-12 and IL-18 compared to CD56dimNK cells. However, activating the NK cells by co-culturing them with the tumor cell line K562 or cross-linking...
CD56-CD16+ NK 细胞亚群与其他 NK 细胞亚群具有相同的形态特征,同样表达多种NK细胞标志物,包括 KIRs、NKG2C、NKp30、CD16a、NKG2D、2B4、CD57、TRAIL、CRTAM 和 CRACC。并且在9235个转录本中只有120个基因存在差异表达。 但是,CD56-CD16+ 细胞表达了一...
Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.2016 "12-0567 was used in Flow cytometry/Cell sorting to investigate a strategy for an HCMV vaccine that aims at the simultaneous activation of innate and adaptive immune responses." ...
In addition, in HCC patients the lower frequency of circulating NKG2D+CD56dimNK cells was associated with larger tumor size and/or higher serum GGT. Noticeably, the frequency of NKG2D+CD56dimNK cells at one month after surgery usually failed to restore in early recurrent patients, and that ...
CD56-CD16+ NK 细胞亚群与其他 NK 细胞亚群具有相同的形态特征,同样表达多种NK细胞标志物,包括 KIRs、NKG2C、NKp30、CD16a、NKG2D、2B4、CD57、TRAIL、CRTAM 和 CRACC。并且在9235个转录本中只有120个基因存在差异表达。 但是,CD56-CD16+ 细胞表达了一种独特的抑制标记谱,具有更高的 LILR 家族和 PDCD1 基因...
Potential of the NKG2D/NKG2DL Axis in NK cell-mediated clearance of the HIV-1 reservoir. Int J Mol Sci. 2019;20:1–20. doi:10.3390/ijms20184490 23. Zhang QY, Zhang X, Su B, et al. Increased early activation of CD56dimCD16dim/- natural killer cells in immunological non-responders ...
Expression of the Vγ2 chain of the TCR, CD56, and NKG2D were determined by flow cytometry. Figure 7A shows CD56 staining of a CD56+ Vγ2+ clone versus a CD56- Vγ2+ clone. Cytotoxicity of each clone was analyzed using a flow cytometry-based assay. Target Daudi cells were labeled ...